A client with nephrotic syndrome is at increased risk of developing thromboembolic events. What is the underlying pathophysiological reason for this increased risk?

A. Incorrect. Hematuria (blood in the urinE. and dysuria (painful urination) are not characteristic manifestations of nephrotic syndrome. Instead, they may indicate other kidney conditions or infections.

B. Incorrect. While clients with nephrotic syndrome may experience increased urine output (polyuriA. and nighttime urination (nocturiA. due to fluid imbalances, these are not the primary clinical manifestations.

C. Correct. Frothy, foamy urine output is a classic sign of nephrotic syndrome due to the presence of excessive protein (proteinuriA. in the urine. This foamy appearance is caused by the high levels of protein, mainly albumin, in the urine.

D. Incorrect. Suprapubic tenderness and urgency are not typical manifestations of nephrotic syndrome and may indicate other urinary tract or bladder issues.

A. Incorrect. Elevated platelet count and clotting factors are not characteristic of nephrotic syndrome. Clients with nephrotic syndrome tend to have normal platelet counts.

B. Incorrect. Decreased blood viscosity and enhanced blood flow would not directly lead to an increased risk of thromboembolic events in nephrotic syndrome.

C. Incorrect. While impaired liver function may impact clotting factors, it is not a common manifestation of nephrotic

syndrome.

D. Correct. Nephrotic syndrome is associated with a loss of anticoagulant proteins, particularly antithrombin III, in the urine. This loss of anticoagulant proteins contributes to a state of hypercoagulability, increasing the risk of thromboembolic events, such as deep vein thrombosis and pulmonary embolism.