A client with nephrotic syndrome is experiencing hyperlipidemia. What is the rationale for elevated lipid levels in this client?
Increased cholesterol synthesis in the liver.
Impaired fat absorption in the small intestine.
Reduced clearance of lipids by the kidneys.
Elevated blood glucose levels and insulin resistance.
The Correct Answer is A
A. In nephrotic syndrome, significant protein loss in the urine (especially albumin) triggers the liver to increase protein synthesis. As part of this compensatory mechanism, the liver also increases lipoprotein production, leading to elevated cholesterol and triglyceride levels. Hyperlipidemia is a common metabolic consequence of nephrotic syndrome.
B. Fat absorption in the small intestine is typically normal; hyperlipidemia in nephrotic syndrome is not caused by malabsorption.
C. The kidneys primarily filter proteins, not lipids. Lipid clearance is not directly reduced by kidney function in nephrotic syndrome, so this is not the main cause of hyperlipidemia.
D. Elevated blood glucose and insulin resistance can contribute to hyperlipidemia in diabetes but are not the primary mechanism in nephrotic syndrome.
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Related Questions
Correct Answer is B
Explanation
A. Incorrect. Elevated blood pressure and fluid overload are more indicative of fluid retention and hypertension in nephrotic syndrome, not hypoalbuminemia.
B. Correct. Hypoalbuminemia, a common feature of nephrotic syndrome, results from the loss of albumin (a protein) in the urine. Low albumin levels can lead to muscle weakness and fatigue due to decreased oncotic pressure in the blood vessels, resulting in fluid shifting from the blood vessels to the interstitial spaces.
C. Incorrect. Hyperactivity and restlessness are not typical manifestations of hypoalbuminemia and nephrotic syndrome.
D. Incorrect. Pallor and cold extremities are not directly related to hypoalbuminemia and are not specific to nephrotic syndrome.
Correct Answer is A
Explanation
A. Correct. Immunosuppressive medications are prescribed in nephrotic syndrome to reduce inflammation in the kidneys and prevent further damage, including kidney scarring. They help slow the progression of the disease and preserve kidney function.
B. Incorrect. Immunosuppressive medications are not primarily used to address fluid overload or improve urinary output in nephrotic syndrome.
C. Incorrect. While some immunosuppressive medications may have an impact on blood glucose levels, they are not typically used to manage diabetes in nephrotic syndrome.
D. Incorrect. Immunosuppressive medications do not directly alleviate pain and discomfort associated with edema in nephrotic syndrome. Other interventions, such as diuretics, are used for managing edema.
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