A nurse develops a delayed hypersensitivity reaction after wearing latex gloves. Which pathophysiologic process is involved in this type of hypersensitive reaction?
Immediate allergic reaction mediated by sensitized mast cells.
Antigen-antibody complexes deposit in tissues activating inflammation.
T-cells sensitization initiates the macrophage release of cytokines causing a delayed reaction.
Antibodies are formed against antigens on cell surfaces.
The Correct Answer is C
A. Immediate allergic reaction mediated by sensitized mast cells. This describes a Type I hypersensitivity reaction, which is an immediate allergic reaction. It involves IgE antibodies and mast cell degranulation, leading to symptoms such as hives, anaphylaxis, and respiratory distress. Latex allergies can involve Type I reactions, but delayed hypersensitivity is a Type IV reaction.
B. Antigen-antibody complexes deposit in tissues activating inflammation. This describes a Type III hypersensitivity reaction, which involves immune complex deposition leading to inflammation, as seen in lupus or serum sickness. Latex allergies do not involve immune complex deposition.
C. T-cells sensitization initiates the macrophage release of cytokines causing a delayed reaction. This describes a Type IV hypersensitivity reaction, which is a delayed-type hypersensitivity (DTH) mediated by T-cells rather than antibodies. In latex-induced delayed hypersensitivity, T-cells recognize latex proteins and release cytokines, leading to localized skin inflammation, rash, and itching, typically 24–48 hours after exposure.
D. Antibodies are formed against antigens on cell surfaces. This describes a Type II hypersensitivity reaction, which involves antibody-mediated destruction of cells, as seen in hemolytic anemia or blood transfusion reactions. Latex allergies do not involve direct antibody attack on cells.
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Related Questions
Correct Answer is D
Explanation
A. Activation of exocytosis. Exocytosis is a cellular process used for releasing substances such as neurotransmitters or hormones, but it is not the primary response to inflammation. The immune response involves chemical mediators like histamine, prostaglandins, and cytokines, which increase vascular permeability.
B. Vasoconstriction. Vasodilation, not vasoconstriction, is a hallmark of inflammation. Initially, there may be a brief period of vasoconstriction, but the primary response is vasodilation, which increases blood flow to the inflamed area.
C. Decreased histamine production. Histamine production increases during inflammation, leading to vasodilation and increased vascular permeability. This allows immune cells to travel to the site of injury or infection.
D. Increased vascular permeability. The inflammatory response involves increased vascular permeability, allowing immune cells, proteins, and fluid to move from the bloodstream into tissues to fight infection and promote healing. This process leads to swelling (edema), redness, and warmth, which are classic signs of inflammation.
Correct Answer is B
Explanation
A. Enzyme immunoassay. The enzyme immunoassay (EIA), also known as the ELISA test, is used as a primary screening test for HIV. If the EIA test is positive, a confirmatory test, such as the Western Blot, is performed to ensure accuracy.
B. Western Blot. The Western Blot is a confirmatory test for HIV used to verify positive results from an initial screening test. It detects specific HIV antibodies and is highly specific, reducing the likelihood of false positives.
C. White blood cell differential. A white blood cell (WBC) differential assesses the overall immune response but does not diagnose HIV. While some HIV patients may show low WBC counts, this test is not specific for HIV infection.
D. CD4+ cell count. CD4+ cell count is used to monitor disease progression and immune function in HIV-positive patients, but it is not a confirmatory test for diagnosing HIV. A low CD4+ count suggests HIV progression toward AIDS rather than initial diagnosis.
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