A nurse instructs the patient that if ciprofloxacin (Cipro) is taken with antacids, absorption is
Not affected
delayed
increased
decreased
The Correct Answer is D
A. Not affected:
This choice suggests that taking ciprofloxacin with antacids does not alter its absorption. However, this is not correct. When ciprofloxacin is taken with antacids containing certain ions (such as aluminum, magnesium, or calcium), the absorption of ciprofloxacin can indeed be affected due to the formation of insoluble complexes, leading to decreased absorption.
B. Delayed:
This choice implies that taking ciprofloxacin with antacids delays its absorption. While it's true that the interaction between ciprofloxacin and certain antacids can alter absorption, the main effect is not typically a delay in absorption but rather a decrease due to the formation of insoluble complexes. Therefore, while "delayed" may somewhat describe the effect, it doesn't fully capture the nature of the interaction.
C. Increased:
This choice suggests that taking ciprofloxacin with antacids increases its absorption. However, this is not accurate. Antacids containing aluminum, magnesium, or calcium can interfere with the absorption of ciprofloxacin by forming insoluble complexes with the drug, leading to decreased absorption rather than an increase.
D. Decreased:
This choice correctly identifies the effect of taking ciprofloxacin with antacids. When ciprofloxacin is taken concurrently with antacids containing aluminum, magnesium, or calcium, the absorption of ciprofloxacin is decreased. The ions in the antacids bind with ciprofloxacin in the gastrointestinal tract, forming insoluble complexes that are poorly absorbed, thereby reducing the effectiveness of the antibiotic.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A.Alcohol:
Alcohol consumption does not directly reduce the absorption of ciprofloxacin. However, alcohol can interact with certain medications and may exacerbate side effects such as dizziness, drowsiness, and gastrointestinal upset. It’s generally advisable to avoid excessive alcohol consumption while taking ciprofloxacin, but alcohol itself does not significantly affect the absorption of the medication.
B. Intense physical exertion:
Intense physical exertion is unlikely to directly reduce the absorption of ciprofloxacin. However, gastrointestinal motility may increase during intense exercise, potentially affecting the absorption of oral medications. In some cases, gastrointestinal disturbances associated with physical exertion may affect the absorption of ciprofloxacin, but this effect is generally minor and not a significant concern for most individuals.
C. Fruit juices, in particular grapefruit juice:
Grapefruit juice is known to interact with certain medications by inhibiting intestinal enzymes responsible for drug metabolism, leading to increased drug concentrations in the bloodstream. However, ciprofloxacin is not significantly affected by grapefruit juice. In fact, fruit juices, including grapefruit juice, are generally not known to reduce the absorption of ciprofloxacin.
D. Antacids or mineral supplements:
Antacids and mineral supplements containing aluminum, magnesium, calcium, or iron can significantly reduce the absorption of ciprofloxacin when taken concurrently. These substances can form complexes with ciprofloxacin in the gastrointestinal tract, reducing its bioavailability. Therefore, it’s recommended to avoid taking antacids or mineral supplements containing these minerals within a few hours before or after taking ciprofloxacin to avoid interference with its absorption.
Correct Answer is B
Explanation
A. Kanamycin (Kantrex):
Kanamycin is an aminoglycoside antibiotic, but it is not commonly used as a first-line treatment for MRSA infections. Aminoglycosides are not typically preferred for treating MRSA because they are not as effective against these resistant bacteria compared to other agents like vancomycin.
B. Vancomycin:
Vancomycin is a glycopeptide antibiotic and is considered the drug of choice for the treatment of MRSA infections, including serious bloodstream infections, pneumonia, and skin and soft tissue infections. It works by inhibiting cell wall synthesis in bacteria, including MRSA.
C. Streptomycin:
Streptomycin is another aminoglycoside antibiotic, similar to kanamycin. Like kanamycin, streptomycin is not typically used as a first-line treatment for MRSA infections because it is less effective against resistant strains compared to other agents like vancomycin.
D. Penicillin:
Penicillin and other beta-lactam antibiotics are ineffective against MRSA because MRSA is resistant to these antibiotics, including methicillin. Therefore, penicillin would not be an appropriate choice for treating MRSA infections.
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