A nurse is administering a proton pump inhibitor (PPI) to a client with gastroesophageal reflux disease (GERD). Which of the following instructions should the nurse provide to the client?

B) Correct. Proton pump inhibitors (PPIs) are most effective when taken on an empty stomach, about 30 minutes before a meal. This ensures optimal absorption and inhibits gastric acid secretion during mealtime.

A) Incorrect. PPIs do not need to be taken with a full glass of water. However, taking them with a small amount of water is recommended to aid in swallowing.

C) Incorrect. PPIs should not be crushed. They are usually in delayed-release or enteric-coated form to protect the medication from stomach acid and facilitate absorption in the small intestine.

D) Incorrect. Taking PPIs right before bedtime is not necessary or recommended unless specifically prescribed by the healthcare provider.

D) Correct. Antacid medications can interfere with the absorption of other medications. Therefore, the client should be advised to avoid taking other medications within 1 hour of taking an antacid.

A) Incorrect. Antacid medications can be taken with or without food, depending on the client's preference or specific instructions from the healthcare provider.

B) Incorrect. Antacid medications do not need to be crushed before swallowing. They are typically available as tablets, chewable tablets, or liquids.

C) Incorrect. Taking antacid medication immediately before bedtime is not necessary or recommended unless specifically prescribed by the healthcare provider. The timing of antacid administration can vary based on the client's symptoms and medication regimen.