A nurse is caring for a client who is taking pseudoephedrine orally to treat allergic rhinitis.
The nurse should assess for which of the following potential adverse effects of this medication?
Polyuria.
Increased appetite.
Bradycardia.
Hypertension.
The Correct Answer is D
Choice A rationale
Pseudoephedrine is a sympathomimetic agent that primarily acts as a vasoconstrictor and bronchodilator. It does not directly affect kidney function to cause polyuria. In fact, due to its vasoconstrictive properties, it could theoretically decrease renal blood flow, although this is not a common or expected adverse effect leading to increased urine output.
Choice B rationale
Pseudoephedrine's primary mechanism of action involves stimulating alpha- and beta-adrenergic receptors. It does not have a known effect on appetite regulation; it is not typically associated with either increased or decreased appetite. Therefore, an increased appetite is not an expected adverse effect of this medication.
Choice C rationale
Pseudoephedrine is a sympathomimetic drug that stimulates adrenergic receptors, leading to effects similar to sympathetic nervous system activation. This stimulation typically results in tachycardia, not bradycardia. It increases heart rate and contractility, which can be problematic for individuals with pre-existing cardiovascular conditions.
Choice D rationale
As a sympathomimetic, pseudoephedrine causes vasoconstriction by stimulating alpha-1 adrenergic receptors in the arterioles. This widespread vasoconstriction leads to an increase in peripheral vascular resistance, which in turn can elevate blood pressure. Therefore, hypertension is a common and important adverse effect to monitor for, especially in individuals with pre-existing hypertension.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale
Distribution refers to the reversible movement of a drug from the systemic circulation to the body's tissues. While food can indirectly influence distribution by altering blood flow or protein binding, its primary and most direct impact on drug pharmacokinetics is not typically on the distribution phase itself.
Choice B rationale
Metabolism, primarily occurring in the liver, involves the biochemical modification of drugs. While some foods can induce or inhibit metabolic enzymes, the direct and immediate effect of the presence of food at the time of administration is typically not on the rate of drug metabolism but rather on the initial entry into the systemic circulation.
Choice C rationale
Excretion is the elimination of drugs from the body, mainly through the kidneys. Food generally does not directly influence the rate of drug excretion, which is primarily dependent on renal function, glomerular filtration, tubular secretion, and reabsorption processes.
Choice D rationale
Absorption is the process by which a drug moves from its site of administration into the bloodstream. The presence of food in the gastrointestinal tract can significantly alter the rate and extent of oral drug absorption by affecting gastric emptying time, pH, drug solubility, and interaction with food components.
Correct Answer is C
Explanation
Choice A rationale
Constipation is not a commonly associated adverse effect of ciprofloxacin. Fluoroquinolones primarily impact gastrointestinal motility through alterations in gut flora and direct irritation, often leading to diarrhea or abdominal discomfort rather than constipation. The drug's mechanism does not typically promote slowed bowel movements or decreased peristalsis.
Choice B rationale
Weight gain is not a typical adverse effect of ciprofloxacin. Fluoroquinolones do not directly influence metabolic pathways or fluid retention in a manner that would lead to increased body mass. Adverse effects are usually related to gastrointestinal disturbances, neurological effects, or musculoskeletal issues.
Choice C rationale
Phototoxicity is a significant adverse effect of ciprofloxacin, a fluoroquinolone antibiotic. This occurs due to the drug's ability to absorb ultraviolet radiation, leading to a photochemical reaction that damages skin cells. This damage can manifest as severe sunburn, blistering, or rash upon exposure to sunlight.
Choice D rationale
Bradycardia is not a recognized adverse effect of ciprofloxacin. While some antibiotics can rarely affect cardiac conduction, ciprofloxacin's primary cardiovascular concerns relate more to QT prolongation and potential arrhythmias, not typically a decrease in heart rate. Its mechanism does not directly depress sinoatrial node function.
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