A nurse is preparing to administer diclofenac to a client who has chronic bursitis.
Which of the following actions should the nurse take?
Administer the medication at bedtime.
Avoid administering the medication with antacids.
Administer the medication with food.
Crush the medication prior to administration.
The Correct Answer is C
Choice A rationale
Administering diclofenac at bedtime does not specifically mitigate its gastrointestinal side effects. NSAIDs like diclofenac can cause gastric irritation and ulceration by inhibiting cyclooxygenase-1 (COX-1), which produces prostaglandins essential for gastric mucosal protection. Time of administration is less critical than co-administration with food or protective agents.
Choice B rationale
Antacids can interfere with the absorption of some medications, but specifically for diclofenac, avoiding concomitant administration is not a standard recommendation to mitigate adverse effects. In fact, antacids can sometimes be used to alleviate gastric distress associated with NSAIDs, although they do not prevent direct mucosal damage.
Choice C rationale
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that can irritate the gastric mucosa, potentially causing dyspepsia, nausea, and ulceration. Administering the medication with food or milk helps to buffer the gastric acid and physically protect the stomach lining, thereby reducing the direct irritant effect on the gastrointestinal tract and enhancing tolerability.
Choice D rationale
Diclofenac is typically formulated as an enteric-coated tablet or delayed-release capsule to protect the stomach from irritation and ensure targeted drug release in the small intestine. Crushing the medication would destroy this protective coating, leading to premature drug release in the stomach, increasing gastric irritation, and potentially reducing therapeutic efficacy.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale
Pseudoephedrine is a sympathomimetic agent that primarily acts as a vasoconstrictor and bronchodilator. It does not directly affect kidney function to cause polyuria. In fact, due to its vasoconstrictive properties, it could theoretically decrease renal blood flow, although this is not a common or expected adverse effect leading to increased urine output.
Choice B rationale
Pseudoephedrine's primary mechanism of action involves stimulating alpha- and beta-adrenergic receptors. It does not have a known effect on appetite regulation; it is not typically associated with either increased or decreased appetite. Therefore, an increased appetite is not an expected adverse effect of this medication.
Choice C rationale
Pseudoephedrine is a sympathomimetic drug that stimulates adrenergic receptors, leading to effects similar to sympathetic nervous system activation. This stimulation typically results in tachycardia, not bradycardia. It increases heart rate and contractility, which can be problematic for individuals with pre-existing cardiovascular conditions.
Choice D rationale
As a sympathomimetic, pseudoephedrine causes vasoconstriction by stimulating alpha-1 adrenergic receptors in the arterioles. This widespread vasoconstriction leads to an increase in peripheral vascular resistance, which in turn can elevate blood pressure. Therefore, hypertension is a common and important adverse effect to monitor for, especially in individuals with pre-existing hypertension.
Correct Answer is A
Explanation
Choice A rationale
Notifying the client's provider is the first and most critical step. The provider needs to be immediately informed of the medication error, as they are responsible for assessing the client's current condition, determining the potential impact of the incorrect medication, and ordering necessary interventions or monitoring.
Choice B rationale
Completing an incident report is important for quality improvement and safety, but it should be done after the immediate safety of the client has been addressed and the provider has been notified. The priority is always patient well-being and clinical management.
Choice C rationale
While reviewing possible adverse effects is part of understanding the situation, the nurse's primary action should be to involve the prescribing authority. The provider can then provide specific guidance for monitoring and management based on the client's individual health status.
Choice D rationale
Administering clonazepam as prescribed should be done once the immediate risk from the clonidine has been assessed and managed, and the provider has given appropriate instructions. Giving the correct medication immediately without assessing the impact of the error could be premature or harmful.
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