A nurse is discussing treatments and interventions with a client who has chronic obstructive pulmonary disease (COPD). Which of the following would assist in preventing exacerbations?

A. Dopamine is primarily associated with other neurodegenerative disorders such as Parkinson's disease, not Alzheimer's disease. In Alzheimer's disease, the focus is on changes related to beta-amyloid plaques and neurofibrillary tangles rather than alterations in dopamine levels.
B. Glial cells, including astrocytes and microglia, play a role in the brain's immune response and support of neurons. In Alzheimer's disease, there is evidence of increased activation and proliferation of glial cells in response to neuroinflammation and the presence of beta-amyloid plaques and neurofibrillary tangles. This reactive gliosis is a secondary response to the underlying pathology.
C. Glutamate is an excitatory neurotransmitter involved in various brain functions, including memory and learning. In Alzheimer's disease, there is evidence of dysregulation in glutamate metabolism and

signaling pathways. This dysregulation can lead to excitotoxicity, which contributes to neuronal damage and cell death seen in the disease.
D. Neurofibrillary tangles are one of the hallmark pathological features of Alzheimer's disease. These tangles are aggregates of hyperphosphorylated tau protein that accumulate inside neurons, disrupting their normal functioning and eventually leading to cell death. Neurofibrillary tangles, along with beta- amyloid plaques, contribute to the progressive cognitive decline observed in Alzheimer's disease.

A. By surrounding themselves with familiar items, such as photos, favorite objects, or comforting decor from their previous home, the resident can feel more at ease and connected to their past. This approach helps in creating a more homelike atmosphere and reducing feelings of disorientation and stress associated with the move.
B. Isolating the resident and encouraging avoidance of social interactions can exacerbate feelings of loneliness, isolation, and anxiety. Avoiding social interactions may prolong feelings of stress and hinder adaptation to the new living situation.
C. While it's important to manage the frequency and timing of visits to ensure the resident is not overwhelmed, outright restricting visitation hours can be counterproductive. Restricting visitation could increase feelings of isolation and loneliness, which are already common in new residents of long-term care facilities.
D. Using sedative medications should be reserved for situations where non-pharmacological interventions have been unsuccessful and the resident's anxiety or distress is severe and persistent. Sedatives can have side effects, especially in older adults, and should not be the first-line approach for managing relocation stress syndrome.