A nurse is preparing to administer aspirin 650 mg PO. Available is aspirin 325 mg tablets.

How many tablets should the nurse administer? (Round to the nearest whole number.

Use a leading zero if it applies.

Do not use a trailing zero.) Tablets.

Choice A rationale:
While distribution can affect a person’s response to medication, it is not the aspect of genetic makeup most likely to alter this response.
Choice B rationale:
Absorption can affect how a drug is taken up by the body, but it is not the aspect of genetic makeup most likely to alter a person’s response to medication.
Choice C rationale:
Excretion, or how the body eliminates a drug, can affect drug response, but it is not the aspect of genetic makeup most likely to alter this response.
Choice D rationale:
Metabolism, or how the body processes a drug, is the aspect of genetic makeup most likely to alter a person’s response to medication. Genetic differences can lead to variations in drug-metabolizing enzymes, affecting how quickly or slowly drugs are metabolized.

Choice A rationale:
While it’s true that hydration affects skin absorption, it’s not accurate to say that water-soluble drugs are not readily absorbed because the skin is not fully hydrated.
Choice B rationale:
Inflammation can actually increase the amount of drug absorbed due to increased blood flow and permeability.
Choice C rationale:
Topical administration with percutaneous absorption can be effective in infants, but it’s not always the case.
Choice D rationale:
Infants wearing plastic-coated diapers are indeed more susceptible to skin absorption. This is because the occlusive nature of the diaper can enhance absorption by increasing the hydration of the skin.