A nurse is providing care with for a client diagnosed with human immunodeficiency virus. The client discusses concerns about transmitting the virus to their family members. What should the nurse include in client education? The nurse teaches the client to:

A) Treatment plan will need to be changed to achieve the desired effect:
The decrease in the carcinoembryonic antigen (CEA) levels from 50 ng/mL to 10 ng/mL suggests that the cancer is responding to the current treatment, not that the treatment plan needs to be changed. A drop in CEA levels typically indicates a positive response to treatment, such as chemotherapy, in reducing the number or size of cancer cells.

B) Cancer treatment is having the desired effect on killing cancer cells:
Carcinoembryonic antigen (CEA) is a tumor marker that is often elevated in individuals with certain cancers, particularly colorectal cancer. A decrease in CEA levels, as noted in this case (from 50 ng/mL to 10 ng/mL), usually signifies that the treatment is successfully targeting the cancer and reducing the tumor burden. This drop suggests that the chemotherapy is effectively killing cancer cells and reducing the size or activity of the tumor.

C) Client is at greater risk for tumor lysis syndrome:
Tumor lysis syndrome typically occurs when large numbers of cancer cells die rapidly, releasing their intracellular contents into the bloodstream, which can lead to metabolic disturbances like hyperkalemia, hyperphosphatemia, and renal failure. It is more common in aggressive hematologic cancers, such as leukemia or lymphoma, and typically presents with a rapid rise in tumor marker levels, not a decrease.

D) Cancer has increased size and metastatic sites:
An increase in tumor size or the development of metastatic sites would typically result in an increase in CEA levels, not a decrease. Since CEA levels have dropped, it is more likely that the cancer is shrinking or responding to the current treatment. This finding is more indicative of a positive response rather than disease progression.

A) 3% Normal Saline:
Elevated ICP can lead to a life-threatening condition known as cerebral herniation, and it often triggers the Cushing’s triad—widened pulse pressure, bradycardia, and irregular respirations, all of which the nurse has noted. Hypertonic saline (such as 3% Normal Saline) is commonly used to manage increased ICP because it creates an osmotic gradient that draws fluid out of the brain tissue, reducing cerebral edema and lowering ICP. The goal is to reduce swelling and prevent further brain damage.

B) Nitroprusside:
Nitroprusside is a potent vasodilator that is used to treat hypertension and reduce afterload in conditions like heart failure or aortic dissection. However, in this case, nitroprusside is contraindicated because it could cause a drop in systemic blood pressure, which would worsen cerebral perfusion in a patient with elevated ICP.

C) Norepinephrine:
Norepinephrine is a vasopressor used to treat hypotension by increasing systemic vascular resistance and blood pressure. Although norepinephrine may be used to support blood pressure in critically ill patients, in this context of elevated ICP, the priority is to reduce ICP, not to increase blood pressure further. Increasing the systemic vascular resistance with norepinephrine could exacerbate ICP by increasing the volume of blood in the cranium

D) Furosemide:
Furosemide is a loop diuretic that can reduce fluid volume and help treat conditions like edema or heart failure. While furosemide can reduce overall fluid volume, it is not typically used to manage elevated ICP in this context. Diuretics like furosemide may have a role in managing cerebral edema, but they are not as effective as hypertonic saline in rapidly reducing ICP.