A patient has a positive Chvostek sign. The nurse interprets this as a sign of:

Choice A reason: Amphotericin B is typically administered intravenously because it is poorly absorbed from the gastrointestinal tract and thus not suitable for oral administration. It is used to treat severe systemic fungal infections and is known for its potential nephrotoxicity and other adverse effects.

Choice B reason: Azoles, such as fluconazole and itraconazole, generally have lower toxicity compared to amphotericin B. They are often used as first-line treatments for many fungal infections due to their safer side effect profile. Azoles work by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, and are available in both oral and intravenous formulations, making them more versatile in their use.

Choice C reason: While amphotericin B does have some drug interactions, it is not typically known for significantly increasing the levels of many other drugs. Instead, the primary concern with amphotericin B is its potential for nephrotoxicity and other direct adverse effects on the patient.

Choice D reason: Both amphotericin B and azoles are considered broad-spectrum antifungal agents. Amphotericin B is effective against a wide range of fungi, including many that are resistant to other antifungal agents. Azoles are also broad-spectrum and are used to treat a variety of fungal infections, but they generally have a better safety profile than amphotericin B.

Choice A reason: Measures to decrease LDL levels in the elderly would indeed affect the progression of cardiovascular disease. Lowering LDL levels through lifestyle changes, medication, or both can significantly reduce the risk of further heart-related events and slow the progression of atherosclerosis. Therefore, this statement is incorrect because managing LDL levels remains crucial for elderly patients with a history of myocardial infarction.

Choice B reason: Increased LDL levels are not specifically indicative of moderate alcohol intake. While excessive alcohol consumption can affect lipid levels, the primary significance of elevated LDL is its association with the risk of cardiovascular disease, not alcohol intake. Therefore, advising patients to abstain from alcohol based solely on increased LDL levels is not a precise recommendation.

Choice C reason: Increased LDL levels are directly associated with an increased risk of coronary artery disease (CAD). LDL, often referred to as "bad cholesterol," contributes to the buildup of plaque in the arteries, which can lead to atherosclerosis. This condition narrows and hardens the arteries, increasing the risk of heart attacks and other cardiovascular events. Monitoring and managing LDL levels is crucial in preventing the progression of CAD, especially in patients with a history of myocardial infarction.

Choice D reason: Elevated LDL levels are not simply an expected finding in the elderly and should not be dismissed as insignificant. Regardless of age, high LDL levels are a significant risk factor for coronary artery disease and other cardiovascular conditions. Elderly patients, particularly those with a history of myocardial infarction, should have their LDL levels monitored and managed to reduce the risk of future heart-related events.