A patient who has type 2 diabetes will begin taking glipizide (Glucotrol). Which statement by the patient is concerning to the nurse?
“I will need to check my blood sugar once daily or more?”
“I may continue to have a glass of wine with dinner.”
“I will begin by taking this once daily with breakfast.”
“It is safe to drink grapefruit juice while taking this drug.”
The Correct Answer is D
Choice A reason: Checking blood sugar daily or more is appropriate for diabetes management with glipizide. This shows understanding, so it is not concerning and incorrect.
Choice B reason: Moderate alcohol (e.g., one glass of wine) is generally safe with glipizide if blood sugar is controlled. This is less concerning than grapefruit, so it’s incorrect.
Choice C reason: Taking glipizide once daily with breakfast is correct, as it enhances insulin release with meals. This is appropriate, so it is not concerning and incorrect.
Choice D reason: Grapefruit juice can inhibit CYP enzymes, potentially increasing glipizide levels and hypoglycemia risk. This misunderstanding is dangerous, making it the correct concerning statement.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A reason: Uncompensated respiratory alkalosis requires low PaCO2 (<35 mm Hg) and high pH (>7.45). Here, PaCO2 is 48 mm Hg (high) and HCO3- is 29 mEq/L (high), indicating a metabolic cause with respiratory compensation, making this choice incorrect.
Choice B reason: Partially compensated respiratory alkalosis involves low PaCO2 and high HCO3- with high pH. With PaCO2 at 48 mm Hg (high) and HCO3- at 29 mEq/L, the alkalosis is metabolic, with elevated PaCO2 as compensation, making this choice incorrect.
Choice C reason: pH 7.48 (alkalotic), PaCO2 48 mm Hg (high), and HCO3- 29 mEq/L (high) indicate metabolic alkalosis (high HCO3-), with elevated PaCO2 showing partial respiratory compensation (hypoventilation to retain CO2). This matches partially compensated metabolic alkalosis, making it the correct choice.
Choice D reason: Uncompensated metabolic alkalosis requires high pH and high HCO3- with normal PaCO2. Here, PaCO2 is 48 mm Hg (high), indicating respiratory compensation, not an uncompensated state. This makes the condition partially compensated, so this choice is less accurate than C.
Correct Answer is ["C","D","E"]
Explanation
Choice A reason: Affinity is not about dosage form but the strength of drug-receptor binding. Dosage is unrelated to receptor interaction, so this is incorrect for affinity’s definition.
Choice B reason: Low affinity means weak attraction to receptors, not strong. High affinity indicates strong binding, so this statement is incorrect.
Choice C reason: High affinity means strong attraction between drug and receptor, enhancing binding and effect. This is accurate, making it a correct choice.
Choice D reason: Affinity influences potency; higher affinity often means greater potency at lower doses. This relationship is correct, making it a correct choice.
Choice E reason: Affinity is the strength of attraction between drug and receptor, a fundamental pharmacological concept. This definition is accurate, so this is a correct choice.
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