A patient with a known heart condition is prescribed an antibiotic before a dental procedure. What type of antibiotic therapy is this considered?
Definitive
Empiric
Supportive
Prophylactic
The Correct Answer is D
Choice A reason: Definitive therapy targets a confirmed infection with antibiotics chosen based on culture results. Prescribing antibiotics before a dental procedure for a heart condition aims to prevent infection, not treat an existing one, making this incorrect for endocarditis prophylaxis.
Choice B reason: Empiric therapy involves antibiotics for suspected infections without confirmed pathogens. Antibiotics before dental procedures in heart patients prevent endocarditis, not treat suspected infections. This is a preventive measure based on risk, not empiric treatment, making this incorrect.
Choice C reason: Supportive therapy addresses symptoms or supports other treatments, not infection prevention. Antibiotics before dental procedures in patients with heart conditions (e.g., valvular disease) prevent bacterial endocarditis, a specific prophylactic measure, not supportive care, making this an incorrect classification.
Choice D reason: Prophylactic antibiotic therapy prevents infections in high-risk patients, such as those with heart conditions (e.g., mitral valve prolapse) before dental procedures. It reduces the risk of bacterial endocarditis from transient bacteremia, aligning with guidelines for prophylaxis in susceptible individuals, making this correct.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: Orange-tinged urine is an expected effect of rifampin, not a therapeutic response. It results from the drug’s red-orange metabolite excreted in urine, not an indicator of tuberculosis resolution. Clinical improvement, like reduced symptoms and negative cultures, better reflects the effectiveness of antitubercular therapy.
Choice B reason: A therapeutic response to antitubercular therapy is indicated by decreased symptoms (e.g., cough, fever), improved chest radiographs (reduced infiltrates), and negative sputum cultures, showing reduced Mycobacterium tuberculosis burden. These objective measures confirm the drugs, like isoniazid and rifampin, are effectively killing the bacteria and resolving the infection.
Choice C reason: Increased tolerance to antitubercular therapy or fewer adverse effects does not indicate a therapeutic response. Tolerance reflects patient adaptation to side effects, not bacterial clearance. Objective measures like symptom reduction and negative cultures are needed to confirm the therapy’s effectiveness against tuberculosis.
Choice D reason: Negative PPD results are not used to monitor active tuberculosis treatment. PPD tests detect latent tuberculosis or prior exposure, not active disease. Therapeutic response is assessed through symptom improvement, chest imaging, and sputum cultures, which directly indicate the reduction of active Mycobacterium tuberculosis infection.
Correct Answer is B
Explanation
Choice A reason: Hair loss is not a common side effect of isoniazid, nor is it prevented by pyridoxine. Isoniazid primarily causes hepatotoxicity or neurotoxicity due to its metabolism and pyridoxine depletion. Hair loss may occur with other drugs, but pyridoxine supplementation is unrelated to this effect.
Choice B reason: Pyridoxine (vitamin B6) is given with isoniazid to prevent peripheral neuropathy. Isoniazid depletes pyridoxine by forming inactive complexes, impairing nerve function and causing numbness or tingling. Supplementation restores pyridoxine levels, protecting peripheral nerves while allowing isoniazid to effectively treat tuberculosis by inhibiting mycolic acid synthesis.
Choice C reason: Heart failure is not associated with isoniazid or prevented by pyridoxine. Isoniazid’s primary toxicities are hepatic and neurological. Pyridoxine supports nerve health, not cardiac function, and heart failure is more linked to drugs like anthracyclines, not antitubercular therapy.
Choice D reason: Renal failure is not a common side effect of isoniazid, nor is it prevented by pyridoxine. Isoniazid is metabolized by the liver, and its toxicities include hepatotoxicity and neuropathy. Pyridoxine addresses neurological side effects, not renal function, making this an incorrect choice.
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