In vitro fertilization-embryo transfer (IVF-ET) is a common approach for women with blocked fallopian tubes or unexplained infertility and for men with very low sperm counts. A husband and wife have arrived for their preprocedural interview. The husband asks the nurse to explain what the procedure entails. The nurse's most appropriate response is:

Choice A reason: Diabetes mellitus is not a direct consequence of inadequate weight gain during pregnancy for the infant. However, maternal diabetes can increase the risk of fetal macrosomia (large birth weight), congenital anomalies, and neonatal hypoglycemia (low blood sugar) in the infant.

Choice B reason: Down syndrome is not a direct consequence of inadequate weight gain during pregnancy for the infant. Down syndrome is a genetic disorder caused by an extra copy of chromosome 21 in the cells of the fetus. The risk of having a baby with Down syndrome increases with maternal age, but it is not related to maternal weight or nutrition².

Choice C reason: Spina bifida is not a direct consequence of inadequate weight gain during pregnancy for the infant. Spina bifida is a neural tube defect that occurs when the spine and spinal cord do not form properly in the fetus. The main risk factor for spina bifida is a lack of folic acid (a B vitamin) in the mother's diet before and during pregnancy.

Choice D reason: Intrauterine growth restriction (IUGR) is a condition in which the fetus does not grow as expected and has a low birth weight. IUGR can have many causes, such as placental problems, infections, chromosomal abnormalities, and maternal factors. One of the maternal factors that can contribute to IUGR is inadequate weight gain during pregnancy, especially in underweight women. IUGR can increase the risk of complications for the infant, such as preterm birth, low Apgar score, hypothermia, hypoglycemia, and breathing problems⁵.

Choice A reason: Low birth weight is not a common complication of GDM, as the fetus tends to grow larger than normal due to the excess glucose and insulin in the blood. Low birth weight is more likely to occur in infants of mothers with preexisting diabetes or other conditions that affect placental function.

Choice B reason: Preterm birth is a possible complication of GDM, as the increased fetal size and the risk of maternal hypertension or infection may induce labor before term. However, it is not the greatest risk for the fetus, as preterm infants can survive with proper care and treatment.

Choice C reason: Macrosomia is the greatest risk for the fetus of a mother with GDM, as it is defined as a birth weight of more than 4000 g or 8 lb 13 oz. Macrosomia can cause difficulties during labor and delivery, such as shoulder dystocia, birth trauma, or cesarean birth. It can also increase the risk of neonatal hypoglycemia, jaundice, or respiratory distress.

Choice D reason: Congenital anomalies of the central nervous system are not a common complication of GDM, as they usually occur in the first trimester of pregnancy, before GDM is diagnosed or develops. Congenital anomalies are more likely to occur in infants of mothers with preexisting diabetes or other genetic or environmental factors.