Signs of fentanyl patch overdose are:.

Choice A rationale:
Perception is one of the phases of nociceptive pain. It involves the awareness of pain, where the brain recognizes and interprets the pain signals. During this phase, the individual becomes conscious of the painful sensation.
Choice B rationale:
Transmission is another phase of nociceptive pain. It involves the propagation of pain signals from the site of injury or damage to the central nervous system. Nerve fibers carry the pain signals to the spinal cord and brain for processing.
Choice D rationale:
Modulation is also a phase of nociceptive pain. It refers to the body's ability to modify or regulate the pain signals. This can involve the release of endorphins or other natural pain-relieving substances that help dampen the pain perception.
Choice E rationale:
Transduction is the last phase of nociceptive pain. It is the process where the noxious stimulus (injury or damage) is converted into electrical nerve signals that the body can understand. This conversion allows the pain signal to travel through the nervous system.
Choice C rationale:
Translation is not typically considered one of the phases of nociceptive pain. While translation may refer to the process of converting one form of information to another, it is not a recognized phase in the context of pain perception.

Choice A rationale:
Endorphins are capable of reducing pain in both physiological and psychological conditions, so this statement is inaccurate.
Choice B rationale:
Endorphins are often described as natural morphine-like compounds, but they are not enzymes. They are neuropeptides produced by the body, which bind to opioid receptors and act as natural painkillers.
Choice D rationale:
Endorphins can reduce pain in response to various stressors, whether they are physiological or psychological. They play a role in the body's response to stress and pain. Therefore, this statement is not accurate.