The client receives 200 mg of a medication on a consistent schedule. How much drug is in the body at 4 half-lives?
387.5
375
393.8
350
The Correct Answer is B
Here's the process for calculating the drug concentration after multiple half-lives:
First half-life: After 1 half-life, 50% of the original dose remains in the body.
200 mg x 0.50 = 100 mg remains after 1 half-life.
Second half-life: After 2 half-lives, 50% of the remaining drug will be eliminated.
100 mg x 0.50 = 50 mg remains after 2 half-lives.
Third half-life: After 3 half-lives, 50% of the remaining drug will be eliminated again.
50 mg x 0.50 = 25 mg remains after 3 half-lives.
Fourth half-life: After 4 half-lives, 50% of the remaining drug will be eliminated once more.
25 mg x 0.50 = 12.5 mg remains after 4 half-lives.
Now, we need to sum up the amount of drug remaining in the body at each half-life:
After 4 half-lives, there are 12.5 mg left from the original dose.
Total drug in the body after 4 half-lives = 200 mg - 12.5 mg = 375 mg.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A) Cerebral Vascular Accident (CVA): While a history of a CVA (stroke) is important to consider when prescribing medications, ondansetron is not contraindicated for clients with a history of CVA. The nurse would need to assess the client’s overall neurological status and risk factors but this condition is not an immediate concern for ondansetron use.
B) Depression: Ondansetron is not typically contraindicated in patients with depression. However, the nurse should be mindful of the potential for interactions with other medications the client may be taking for depression, but there is no direct contraindication between ondansetron and depression itself.
C) Glaucoma: This is the most concerning finding. Ondansetron can increase the risk of complications in clients with glaucoma, particularly narrow-angle glaucoma. Ondansetron has some serotonin receptor-blocking properties that can cause dilation of the pupil, which could increase intraocular pressure in clients with glaucoma. Therefore, this condition would require careful monitoring, and the nurse would need to consult with the healthcare provider before administering ondansetron to a client with glaucoma.
D) Congestive Heart Failure (CHF): While patients with CHF need to be monitored for fluid balance, ondansetron is not contraindicated in clients with CHF. The primary concern in these patients would be potential fluid retention or electrolyte imbalances, but this is generally not a direct concern for the administration of ondansetron itself.
Correct Answer is B
Explanation
A) Right dose: The right dose was administered. The order specifies 1000 mg of
acetaminophen, and the nurse gave 1000 mg. Therefore, the right dose was given, and this is not the issue in this situation.
B) Right route: The right route was not followed in this situation. The order specifies that acetaminophen should be administered IV, but the nurse administered the medication PO. The route of administration is crucial for ensuring the medication is delivered in the appropriate manner for the intended therapeutic effect. By giving the medication orally instead of intravenously, the nurse deviated from the prescribed route, which is a violation of the "right route."
C) Right reason: The right reason was followed because acetaminophen is commonly given for pain or fever management, and no information suggests the wrong reason for administering the drug. The nurse's action doesn’t indicate a mistake in the reasoning for giving the medication.
D) Right time: The right time is not affected here, as the nurse did administer the acetaminophen at the scheduled time. The issue is with the route, not the timing.
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