A client who weighs 45kg is ordered to receive 500 mg of amoxicillin every eight hours. The dosing range noted in the Davis Drug Guide is 20 to 40 mg/kg/day divided and to be given every 8 hours. True or False: the client's dose is safe and therapeutic?

True

False

Answer and Explanation

The Correct Answer is A

To determine if the client's dose is safe and therapeutic, we need to calculate the appropriate dosing range based on the client's weight and compare it with the ordered dose.

Client's weight: 45 kg

Ordered dose: 500 mg every 8 hours, which equals 1500 mg/day (500 mg × 3 doses).

Calculate the therapeutic range:

The dosing range in the Davis Drug Guide is 20 to 40 mg/kg/day. So, for this client, based on their weight of 45 kg:

Minimum dose: 20 mg × 45 kg = 900 mg/day

Maximum dose: 40 mg × 45 kg = 1800 mg/day

The ordered dose of 1500 mg/day falls within this range (900 mg/day to 1800 mg/day), which means it is safe and therapeutic for the client.

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Correct Answer is B

Explanation

Here's the process for calculating the drug concentration after multiple half-lives:

First half-life: After 1 half-life, 50% of the original dose remains in the body.

200 mg x 0.50 = 100 mg remains after 1 half-life.

Second half-life: After 2 half-lives, 50% of the remaining drug will be eliminated.

100 mg x 0.50 = 50 mg remains after 2 half-lives.

Third half-life: After 3 half-lives, 50% of the remaining drug will be eliminated again.

50 mg x 0.50 = 25 mg remains after 3 half-lives.

Fourth half-life: After 4 half-lives, 50% of the remaining drug will be eliminated once more.

25 mg x 0.50 = 12.5 mg remains after 4 half-lives.

Now, we need to sum up the amount of drug remaining in the body at each half-life:

After 4 half-lives, there are 12.5 mg left from the original dose.

Total drug in the body after 4 half-lives = 200 mg - 12.5 mg = 375 mg.

A. 50 B. 100 C. 25 D. 75

Correct Answer is C

Explanation

Here’s the step-by-step process:

After the first half-life (1 half-life), 50% of the initial drug is left.

200 mg → 100 mg (half is eliminated, 100 mg remains).

After the second half-life (2 half-lives), 50% of the remaining drug is eliminated again.

100 mg → 50 mg (half of 100 mg is eliminated, 50 mg remains).

After the third half-life (3 half-lives), 50% of the remaining drug is eliminated again.

50 mg → 25 mg (half of 50 mg is eliminated, 25 mg remains).

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A client who weighs 45kg is ordered to receive 500 mg of amoxicillin every eight hours. The dosing range noted in the Davis Drug Guide is 20 to 40 mg/kg/day divided and to be given every 8 hours. True or False: the client's dose is safe and therapeutic?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The client receives 200 mg of a medication on a consistent schedule. How much drug is in the body at 4 half-lives?

Correct Answer is B

Explanation

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Correct Answer is C

Explanation

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