The nurse is caring for a client taking fluoxetine for depression. Which assessment findings indicate that the medication is effective? (Select all that apply.)

A. An allergic reaction is a possible response to medication, but it is not directly related to doubling the dosage.

B. Anaphylactic reaction is a severe and rapid allergic response; while possible, it is not the most likely consequence of an overdose in this context.

C. Poisoning is a likely concern when a client takes double the prescribed dosage of analgesics, especially if the medication has a narrow therapeutic index or is known to cause toxicity at high doses.

D. Sedative effects could occur depending on the analgesic used, but poisoning is a more pressing concern following an overdose.

A. While historical context is useful, the development of antimicrobials primarily began in the early 20th century, notably with penicillin discovered by Alexander Fleming in 1928.

B. This statement is incorrect; fluoroquinolones primarily inhibit bacterial DNA synthesis rather than directly affecting the cell wall.

C. Selective toxicity is a principle of antimicrobial action but does not directly explain how a specific antimicrobial works therapeutically.

D. Penicillin specifically interferes with the synthesis of the bacterial cell wall, leading to cell lysis and death of the bacteria, which is a fundamental mechanism of action for this antibiotic.