The practical nurse (PN) is preparing cefazolin 400 mg IM for a client with a gram-positive infection. The available vial is labeled, "Cefazolin 1 gram," and the instructions for reconstitution state, for IM use, add 2 mL sterile water for injection. Total volume after reconstitution is 2.5 mL. After reconstitution, how many mL should be administered to the client? (Enter numeric value only. If rounding is required, round to the whole number, nearest tenths/hundredth).

Choice A rationale:

Aspirin is not typically contraindicated in a client who has taken sildenafil unless there are specific contraindications or allergies. Aspirin is often used in the management of acute chest pain to help prevent blood clot formation.

Choice B rationale:

Heparin is not contraindicated solely because the client has taken sildenafil. Heparin is an anticoagulant commonly used in various clinical settings, including the management of certain cardiac conditions.

Choice C rationale:

Morphine is not necessarily contraindicated based solely on the client's use of sildenafil. Morphine can be used to relieve chest pain in some cases of acute coronary syndrome. However, its use should be carefully evaluated based on the client's overall clinical presentation.

Choice D rationale:

Nitroglycerin should be withheld in this scenario. Sildenafil is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It can potentiate the vasodilatory effects of nitroglycerin, leading to a severe drop in blood pressure. Concomitant use of nitroglycerin and sildenafil is contraindicated due to the risk of significant hypotension, which can be life-threatening.

The correct answer is: D. Blood pressure 90/76 mm Hg.

Clonidine is an alpha-2 adrenergic agonist used to manage withdrawal symptoms, but it lowers blood pressure as a side effect. If the client's blood pressure is already low (90/76 mm Hg), administering clonidine could lead to hypotension, putting them at risk for dizziness, fainting, or more severe complications.

Here's why the other options are not contraindications:

• A. Hypertension: Clonidine is actually used to treat high blood pressure, so it wouldn’t be a contraindication.

• B. Apical heart rate 72 beats/minute: This heart rate is within normal limits, so it wouldn’t prevent administration.

• C. Muscle weakness: While clonidine can cause fatigue, muscle weakness is not a direct contraindication.

Since the client is experiencing withdrawal symptoms like nervousness and unusual sensations ("bones itching"), monitoring vital signs is critical before giving the medication.