What concept is considered when generic drugs are substituted for brand-name drugs?
Half Life.
Critical concentration.
Distribution.
Bioavailability.
The Correct Answer is D
Choice A rationale
The half-life of a drug refers to the time it takes for the plasma concentration of a drug to reduce by half. It is not a primary consideration when substituting generic drugs for brand-name drugs.
Choice B rationale
Critical concentration is the amount of a drug needed to achieve therapeutic effects. While important, it is not the main factor in generic substitution.
Choice C rationale
Distribution describes how a drug is dispersed throughout the body's tissues and fluids. This factor is crucial for drug efficacy but not directly related to substituting generic drugs.
Choice D rationale
Bioavailability is the degree and rate at which an active drug ingredient is absorbed and becomes available at the site of action. Generic drugs must have the same bioavailability as brand-name drugs to ensure they are just as effective.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A rationale
Calcium and magnesium imbalances are less likely to influence Digoxin's effects compared to potassium and magnesium.
Choice B rationale
While chloride levels are important, potassium is more critical due to its significant impact on Digoxin’s action.
Choice C rationale
Correct, potassium and magnesium levels are crucial as imbalances can potentiate Digoxin toxicity or reduce its efficacy.
Choice D rationale
Sodium and calcium imbalances are less directly related to Digoxin efficacy compared to potassium and magnesium.
Correct Answer is D
Explanation
Choice A rationale
Increased jugular venous pressure is more commonly associated with right-sided heart failure, where blood backs up into the venous system.
Choice B rationale
Liver enlargement is also indicative of right-sided heart failure due to congestion of the liver blood vessels.
Choice C rationale
Increased pulse rate can occur in both left and right-sided heart failure but is not a specific indicator of worsening left-sided failure.
Choice D rationale
Increased crackles in lung fields indicate fluid accumulation in the lungs, a sign of worsening left-sided heart failure. Left-sided heart failure leads to pulmonary congestion due to inadequate pumping of blood from the left ventricle.
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