What concept is considered when generic drugs are substituted for brand-name drugs?
Half Life.
Critical concentration.
Distribution.
Bioavailability.
The Correct Answer is D
Choice A rationale
The half-life of a drug refers to the time it takes for the plasma concentration of a drug to reduce by half. It is not a primary consideration when substituting generic drugs for brand-name drugs.
Choice B rationale
Critical concentration is the amount of a drug needed to achieve therapeutic effects. While important, it is not the main factor in generic substitution.
Choice C rationale
Distribution describes how a drug is dispersed throughout the body's tissues and fluids. This factor is crucial for drug efficacy but not directly related to substituting generic drugs.
Choice D rationale
Bioavailability is the degree and rate at which an active drug ingredient is absorbed and becomes available at the site of action. Generic drugs must have the same bioavailability as brand-name drugs to ensure they are just as effective.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale
This choice is incorrect. Cholinergic agonists primarily affect acetylcholine receptors, not GABA receptors. GABA receptors are involved in the inhibitory neurotransmission in the central nervous system and are the target of different drug classes, such as benzodiazepines and barbiturates, which are not related to cholinergic agonists.
Choice B rationale
This choice is incorrect. Cholinergic agonists do not decrease norepinephrine activity. Norepinephrine is a neurotransmitter involved in the sympathetic nervous system response, which is different from the cholinergic system. Drugs that decrease norepinephrine activity would have a different mechanism of action, such as adrenergic antagonists.
Choice C rationale
This choice is incorrect. The primary action of cholinergic agonists is not to increase dopamine activity. Dopamine is another neurotransmitter involved in various brain functions, including reward and motor control. Cholinergic agonists specifically target acetylcholine receptors, enhancing their activity, which is not related to dopamine receptors.
Choice D rationale
This choice is correct. Cholinergic agonists increase the activity of acetylcholine receptor sites throughout the body. These drugs mimic the action of acetylcholine, a neurotransmitter that plays a key role in the parasympathetic nervous system, which regulates functions such as muscle contraction, gland secretion, and heart rate. Enhancing acetylcholine activity helps in conditions like myasthenia gravis and certain types of glaucoma.
Correct Answer is B
Explanation
Choice A rationale
Administering amoxicillin when a patient has a known allergy to penicillin can result in a serious allergic reaction. It is important to avoid using any beta-lactam antibiotic in patients with a history of penicillin allergy.
Choice B rationale
Contacting the provider to discuss using a different antibiotic is the safest course of action. The provider can prescribe an alternative antibiotic that does not belong to the beta-lactam class, reducing the risk of an allergic reaction.
Choice C rationale
Asking the provider to order an antihistamine does not address the underlying risk of administering a beta-lactam antibiotic to a patient with a penicillin allergy. Antihistamines are used to manage allergic reactions, not to prevent them.
Choice D rationale
Requesting an order for a beta-lactamase resistant drug does not eliminate the risk of an allergic reaction, as these drugs still belong to the beta-lactam class and can trigger the same allergic responses in sensitive individuals.
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