What is the initiating event that leads to the development of atherosclerosis?
Injury to the endothelial cells that line the artery walls
Release of the platelet-deprived growth factor
Macrophages adhere to vessel walls
Release of the inflammatory cytokines
The Correct Answer is A
A. Injury to the endothelial cells that line the artery walls: The development of atherosclerosis begins with damage to the endothelial cells of the arterial wall. This injury can be caused by various factors, including hypertension, smoking, high cholesterol, and diabetes. Once the endothelium is injured, it becomes more permeable, allowing lipids and inflammatory cells to penetrate and accumulate, leading to the formation of atherosclerotic plaques.
B. Release of the platelet-derived growth factor: While platelet-derived growth factor (PDGF) plays a role in the proliferation of smooth muscle cells and the progression of atherosclerosis, it is not the initiating event. PDGF is released in response to endothelial injury and inflammation but does not cause the initial damage itself.
C. Macrophages adhere to vessel walls: The adherence of macrophages to the vessel walls occurs after the initial endothelial injury. Once the endothelium is damaged, macrophages migrate to the site and contribute to the inflammatory response and plaque formation, but this is not the initiating event.
D. Release of inflammatory cytokines: Inflammatory cytokines are part of the response that follows endothelial injury and play a role in the progression of atherosclerosis. However, the release of these cytokines is a consequence of the initial injury rather than the initiating event.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
A. Hospital-acquired pneumonia: Pneumonia that develops 48 hours or more after hospital admission is classified as hospital-acquired pneumonia (HAP). It is caused by pathogens acquired in the hospital setting, often involving multidrug-resistant organisms such as Pseudomonas aeruginosa, Staphylococcus aureus (including MRSA), and Klebsiella pneumoniae. Patients who are intubated, have prolonged hospital stays, or have weakened immune defenses are at higher risk.
B. Immunocompromised pneumonia: Pneumonia in immunocompromised patients occurs due to weakened host defenses, such as in individuals with HIV/AIDS, those undergoing chemotherapy, or transplant recipients on immunosuppressive therapy. While these patients can develop HAP, pneumonia due to opportunistic infections like Pneumocystis jirovecii or fungal infections is categorized separately.
C. Community-acquired pneumonia: Pneumonia acquired outside the hospital or within the first 48 hours of admission is classified as community-acquired pneumonia (CAP). Typical pathogens include Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae. CAP is usually less resistant to antibiotics compared to HAP.
D. Viral pneumonia: Pneumonia caused by viral pathogens such as influenza, respiratory syncytial virus (RSV), or SARS-CoV-2 is classified based on the causative agent rather than the setting in which it was acquired. Although viruses can cause both CAP and HAP, the classification of pneumonia is determined by the timing of onset and exposure risks.
Correct Answer is D
Explanation
A. Inflammation: Inflammation refers to the body's immune response to injury or infection and does not specifically denote a temporary deprivation of blood supply to a cell. It is characterized by redness, swelling, heat, and pain in the affected area.
B. Necrosis: Necrosis is the process of cell death that occurs when cells are irreversibly damaged, often due to a lack of blood supply or other injury. It is a consequence of prolonged ischemia rather than the temporary condition itself.
C. Infarction: Infarction refers to the death of tissue due to prolonged ischemia, resulting from an irreversible loss of blood supply. It indicates permanent damage and is not synonymous with a temporary deprivation of blood supply.
D. Ischemia: Ischemia is the term used to describe a temporary reduction in blood flow to a tissue or organ, resulting in a deficiency of oxygen and nutrients. This condition can lead to symptoms and may cause damage if prolonged, making it the correct answer for this scenario.
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