Which classification of diabetes mellitus is characterized by an autoimmune destruction of pancreatic beta cells, resulting in an absolute insulin deficiency?

Weight loss despite increased appetite (polyphagia) is a clinical manifestation of diabetes mellitus due to the body's inability to effectively use glucose for energy, leading to breakdown of muscle and fat tissue.

Incorrect choices:

b. This choice is incorrect. Nausea, vomiting, and abdominal pain are not directly related to weight loss despite increased appetite.

c. This choice is incorrect. Impaired wound healing and increased susceptibility to infections are consequences of chronic hyperglycemia, but they are not directly related to weight loss.

d. This choice is incorrect. Rapid weight gain and bloating are not characteristic manifestations of diabetes mellitus; weight loss is more common.

Basal-bolus insulin therapy involves administering a continuous basal insulin infusion to provide background insulin coverage and delivering bolus doses of insulin before meals to cover postprandial glucose elevations.

Incorrect choices:

a. This choice is incorrect. Oral antidiabetic medications are not used in basal-bolus insulin therapy.

c. This choice is incorrect. Sliding-scale insulin therapy involves adjusting insulin doses based on current blood glucose levels, rather than providing consistent basal and mealtime coverage.

d. This choice is incorrect. Insulin glargine therapy provides long-acting basal insulin coverage but does not involve bolus doses before meals.