Which combinations of drugs have been found to be effective in managing the pain associated with musculoskeletal and soft tissue inflammation?

Opioid agonists and opioid antagonists

Adjuvants and partial agonists

Nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids

NSAIDs and antidepressants

Answer and Explanation

The Correct Answer is C

A. Opioid agonists and opioid antagonists are incorrect because opioid antagonists (e.g., naloxone) reverse opioid effects rather than enhance pain relief.
B. Adjuvants and partial agonists are incorrect because while adjuvants can be helpful, partial agonists may not provide adequate pain relief for severe musculoskeletal pain.
C. NSAIDs and opioids are correct as NSAIDs reduce inflammation and opioids provide stronger analgesia when needed for severe pain.
D. NSAIDs and antidepressants are incorrect because while some antidepressants help with chronic neuropathic pain, they are not the primary treatment for musculoskeletal and soft tissue inflammation.

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Correct Answer is C

Explanation

A. Sodium Bicarbonate is incorrect as it is not a first-line treatment for VF. It may be considered in cases of severe acidosis or hyperkalemia.
B. Amiodarone is incorrect as it is used as an antiarrhythmic, but epinephrine is administered first during cardiac arrest to increase perfusion.
C. Epinephrine is correct because it is the first-line drug given in ventricular fibrillation that persists after defibrillation. It increases coronary and cerebral perfusion and enhances the effectiveness of subsequent defibrillation attempts.
D. Lidocaine is incorrect as it is an antiarrhythmic that may be considered after epinephrine and amiodarone, but it is not the first choice.

A. "Administer an enema to yourself every third day." B. "Constipation is nothing to worry about; take your medicine." C. "Only take morphine when you have the most severe pain." D. "Increase fluids and high-fiber foods, and use a mild laxative."

Correct Answer is D

Explanation

A. Administering an enema every third day may be too infrequent to effectively manage constipation. Enemas are generally not a first-line solution for constipation prevention in patients on long-term opioid therapy.
B. Constipation is nothing to worry about; take your medicine is incorrect because constipation is a common and preventable side effect of opioid use. It should be addressed proactively.
C. Only taking morphine when experiencing the most severe pain could lead to uncontrolled pain. It is important for cancer pain to be managed consistently, and adjusting the timing of medication is not recommended.
D. Increasing fluids and high-fiber foods, and using a mild laxative is the most appropriate recommendation. It helps prevent constipation, which is a common side effect of opioid use. Mild laxatives can also be helpful, but regular bowel care is essential.

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Which combinations of drugs have been found to be effective in managing the pain associated with musculoskeletal and soft tissue inflammation?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The nurse and the other members of the team are caring for a client in the ED who converted to ventricular fibrillation (VF). The client was defibrillated unsuccessfully and the client remains in VF. Which medication should the nurse be prepared to administer?

Correct Answer is C

Explanation

A client with cancer pain is taking morphine for pain relief. Knowing constipation is a common side effect, what would the nurse recommend to the client?

Correct Answer is D

Explanation

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Which combinations of drugs have been found to be effective in managing the pain associated with musculoskeletal and soft tissue inflammation?

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