Which of following best described the mechanism of action for Donepezil (Aricept)?
Prevent breakdown of acetylcholinesterase by inhibiting the action of acetylcholine
Prevent breakdown of acetylcholine by inhibiting the action of acetylcholinesterase
Promote breakdown of acetylcholine by inhibiting the action of acetylcholinesterase
Promote breakdown of acetylcholinesterase by inhibiting the action of acetylcholine
The Correct Answer is B
A. Prevent breakdown of acetylcholinesterase by inhibiting the action of acetylcholine is incorrect because the mechanism of Donepezil (Aricept) involves inhibiting acetylcholinesterase, not acetylcholine itself. The goal is to increase the levels of acetylcholine in the brain by preventing its breakdown.
B. Prevent breakdown of acetylcholine by inhibiting the action of acetylcholinesterase is the correct mechanism. Donepezil is a cholinesterase inhibitor. By inhibiting acetylcholinesterase (the enzyme that breaks down acetylcholine), Donepezil increases the amount of acetylcholine available to stimulate receptors in the brain, which helps improve symptoms of Alzheimer's disease.
C. Promote breakdown of acetylcholine by inhibiting the action of acetylcholinesterase is incorrect because Donepezil prevents the breakdown of acetylcholine, not promotes it.
D. Promote breakdown of acetylcholinesterase by inhibiting the action of acetylcholine is also incorrect. The purpose of Donepezil is to prevent the breakdown of acetylcholine, not to break down acetylcholinesterase itself.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Lewy body disease is a progressive neurological disorder that affects cognition, movement, and behavior. However, it is primarily characterized by symptoms like visual hallucinations, fluctuating cognitive abilities, and Parkinsonism, not primarily uncontrolled movements as in Huntington's disease.
B. Traumatic brain injury (TBI) refers to damage to the brain due to external physical force, such as from a fall or accident. While TBI can lead to cognitive and emotional changes, it does not cause the uncontrolled movements seen in Huntington's disease.
C. Huntington chorea is a progressive brain disorder caused by a genetic mutation. It is characterized by uncontrolled movements (chorea), emotional problems, and cognitive dysfunction. It primarily affects movement, mood, and cognitive function over time.
D. Alzheimer's disease is a progressive neurodegenerative disease primarily characterized by memory loss, confusion, and cognitive decline. It does not typically cause uncontrolled movements like those seen in Huntington's disease.
Correct Answer is A
Explanation
A. Multiple sclerosis (MS) is a disabling disease of the central nervous system (brain and spinal cord). It involves the immune system attacking the protective myelin sheath covering nerve fibers, causing communication problems between the brain and the rest of the body. This progressive damage can lead to both physical and cognitive disabilities, making it a dementia-related disorder in some advanced cases.
B. Huntington chorea (Huntington’s disease) is a genetic neurodegenerative disorder that affects movement and cognitive function, but it is not primarily defined as a disorder of both the brain and spinal cord.
C. Wernicke-Korsakoff syndrome is a brain disorder linked to chronic alcohol use and thiamine (vitamin B1) deficiency. It affects memory and coordination but is not a disease of the spinal cord.
D. Alzheimer’s disease is the most common form of dementia and is strictly a brain disorder, not one that affects the spinal cord.
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