Which statement made by the nurse explains the rationale for the use of donepezil for clients diagnosed with Alzheimer's dementia?
Donepezil increases the availability of acetylcholine at cholinergic synapses.
Donepezil decreases acetylcholine in the periphery to increase movement.
Donepezil delays transmission of acetylcholine at the neuronal junction.
Donepezil works to bind the dopamine at neuron receptor sites to increase ability.
The Correct Answer is A
Donepezil is a medication used to treat Alzheimer's dementia. Its main mechanism of action is the inhibition of the acetylcholinesterase enzyme in the brain ¹. This increases the availability of acetylcholine at cholinergic synapses ⁵, which can improve cognition and function in clients with Alzheimer's dementia ¹.
Option B is incorrect because donepezil does not decrease acetylcholine in the periphery to increase movement.
Option C is incorrect because donepezil does not delay the transmission of acetylcholine at the neuronal junction.
Option D is incorrect because donepezil does not bind dopamine at neuron receptor sites to increase ability.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
In pharmacodynamics, receptors play a crucial role in mediating the effects of medications ¹. Medications must bind with receptors to mimic or block the actions of the body's own regulatory molecules ¹. This binding can activate or inhibit the receptor, leading to a biological response ¹.
Option B is incorrect because activation of the receptor by the medication does not necessarily cause the cell to develop a new function.
Option C is incorrect because receptors do not start the process of metabolism of the medication by the liver.
Option D is incorrect because binding a medication to a receptor does not necessarily make the medication more selective to that type of receptor.
Correct Answer is A
Explanation
Anaphylaxis is a severe and potentially life-threatening allergic reaction that can occur when the body's immune system overreacts to a substance, such as a medication. It is a medical emergency that requires immediate treatment.
Options b, c, and d are not correct because they do not accurately describe the term for a life-threatening response by the body's immune system following the administration of a medication.
Option B refers to the desired effect of a medication, which is not related to anaphylaxis.
Option C refers to a teratogenic effect, which is an effect that can cause harm to a developing fetus.
Option D refers to a paradoxical effect, which is an effect that is opposite to what would be expected.
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