Which statement made by the nurse explains the rationale for the use of donepezil for clients diagnosed with Alzheimer's dementia?
Donepezil increases the availability of acetylcholine at cholinergic synapses.
Donepezil decreases acetylcholine in the periphery to increase movement.
Donepezil delays transmission of acetylcholine at the neuronal junction.
Donepezil works to bind the dopamine at neuron receptor sites to increase ability.
The Correct Answer is A
Donepezil is a medication used to treat Alzheimer's dementia. Its main mechanism of action is the inhibition of the acetylcholinesterase enzyme in the brain ¹. This increases the availability of acetylcholine at cholinergic synapses ⁵, which can improve cognition and function in clients with Alzheimer's dementia ¹.
Option B is incorrect because donepezil does not decrease acetylcholine in the periphery to increase movement.
Option C is incorrect because donepezil does not delay the transmission of acetylcholine at the neuronal junction.
Option D is incorrect because donepezil does not bind dopamine at neuron receptor sites to increase ability.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
An agonist is a molecule that can bind to and activate a receptor to induce a biological response ³. Agonists can be endogenous molecules, such as hormones or neurotransmitters, or medications that mimic the action of endogenous agonists ³.
Option A is incorrect because an agonist does not prevent receptor activation by other medications.
Option C is incorrect because an agonist does not increase the affinity of a receptor for a different medication.
Option D is incorrect because an agonist does not both block and activate a receptor.
Correct Answer is B
Explanation
The therapeutic range for valproic acid is 50-100 mcg/mL ¹. In this case, the client has a serum range for valproic acid of 130 mcg/mL, which is above the therapeutic range but below the toxic level of >100 mcg/mL ¹. The nurse would anticipate that the provider will increase the daily dose of valproic acid to bring the serum range within the therapeutic range.
Option A is incorrect because the serum range is above the therapeutic range and changes may be needed.
Option C is incorrect because changing the medication may not be necessary if adjusting the dose can bring the serum range within the therapeutic range.
Option D is incorrect because decreasing the dose would lower the serum range further below the therapeutic range.
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