A client diagnosed with liver disease asks the nurse why the health care provider is changing the dose of the client’s medications. Which statement is the nurse’s best response?
You should really ask your health care provider
The health care provider is afraid you will become dependent on the medications
The usual dose of medication may be too large for your liver
The affinity of the medication changes with liver disease
The Correct Answer is C
Choice A reason: Redirecting the client to the provider avoids addressing the question and misses an educational opportunity. Liver disease affects drug metabolism, and the nurse can explain this. This response is inappropriate, as it fails to provide the client with accurate information about their medication adjustments.
Choice B reason: Medication dose changes in liver disease are due to impaired metabolism, not dependency concerns. Dependency is unrelated to hepatic function or pharmacokinetics. This statement is inaccurate, as it misrepresents the reason for dose adjustments in the context of liver disease.
Choice C reason: Liver disease impairs drug metabolism via cytochrome P450 enzymes, reducing clearance and increasing drug levels, risking toxicity. Dose adjustments prevent adverse effects. This statement is accurate, as it directly addresses how liver dysfunction necessitates lower doses for safe and effective medication use.
Choice D reason: Medication affinity (binding to receptors) is not significantly altered by liver disease. Instead, impaired hepatic metabolism affects drug clearance, not receptor interactions. This statement is inaccurate, as it misattributes dose changes to a pharmacological property unrelated to liver function.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A reason: Redirecting the client to the provider avoids addressing the question and misses an educational opportunity. Liver disease affects drug metabolism, and the nurse can explain this. This response is inappropriate, as it fails to provide the client with accurate information about their medication adjustments.
Choice B reason: Medication dose changes in liver disease are due to impaired metabolism, not dependency concerns. Dependency is unrelated to hepatic function or pharmacokinetics. This statement is inaccurate, as it misrepresents the reason for dose adjustments in the context of liver disease.
Choice C reason: Liver disease impairs drug metabolism via cytochrome P450 enzymes, reducing clearance and increasing drug levels, risking toxicity. Dose adjustments prevent adverse effects. This statement is accurate, as it directly addresses how liver dysfunction necessitates lower doses for safe and effective medication use.
Choice D reason: Medication affinity (binding to receptors) is not significantly altered by liver disease. Instead, impaired hepatic metabolism affects drug clearance, not receptor interactions. This statement is inaccurate, as it misattributes dose changes to a pharmacological property unrelated to liver function.
Correct Answer is B
Explanation
Choice A reason: Semaglutide, a GLP-1 receptor agonist, is not considered safe in pregnancy due to limited data and potential fetal risks. Animal studies suggest possible teratogenicity, and it is typically avoided in pregnant patients with type 2 diabetes, making this statement inaccurate and irrelevant to its mechanism.
Choice B reason: Semaglutide mimics GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety. These actions lower blood glucose and support weight loss in type 2 diabetes. This statement is accurate, as GLP-1-mediated insulin production is central to its mechanism of action.
Choice C reason: Semaglutide is primarily used for type 2 diabetes, not type 1, as it relies on functional beta cells to enhance insulin secretion. Type 1 diabetes involves absolute insulin deficiency, rendering GLP-1 agonists ineffective. This statement is inaccurate, as semaglutide is not indicated for type 1 diabetes.
Choice D reason: Semaglutide requires regular blood sugar monitoring, as hypoglycemia can occur, especially with concomitant insulin or sulfonylureas. Its glucose-lowering effects necessitate careful management to prevent adverse events. This statement is inaccurate, as monitoring remains critical to ensure safe and effective diabetes control.
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