A client experiencing exophthalmos is seen in a primary care provider's clinic. The nurse understands that the most likely endocrine disorder which would cause this symptom is which of the following?

A. The late-phase response in asthma is characterized by a delayed and prolonged inflammatory reaction that can occur 4 to 6 hours after exposure to a trigger. It involves the recruitment of additional inflammatory cells, such as eosinophils and T cells, which contribute to ongoing airway inflammation, increased mucus production, and bronchoconstriction. This phase often leads to a return of symptoms or worsening of symptoms after the initial relief provided by a rescue inhaler.
B. The late-phase response does not typically respond as well to rescue inhalers (such as albuterol) as the early-phase response does. Rescue inhalers are primarily effective for the immediate, bronchospastic component of asthma (early-phase response).
C. The late-phase response occurs as part of the natural progression of asthma inflammation and is not necessarily related to improper use of a rescue inhaler. Even with proper use of a rescue inhaler, the late-phase response can still occur due to the underlying inflammatory processes.
D. The late-phase response can occur even if the trigger is no longer present. It is related to the ongoing inflammatory process rather than continued exposure to the trigger. Although continued exposure to triggers can exacerbate symptoms, the late-phase response can still occur independently of further exposure.

A. Estrogen's role in temperature regulation is not as significant as other factors in the context of aging and body temperature maintenance.
B. Increased blood pressure itself does not directly influence the ability to maintain body temperature. While hypertension can have various effects on cardiovascular health, it is not a primary factor in the regulation of body temperature in older adults.
C. Decreased muscle strength and tone are significant factors affecting temperature regulation. Muscle activity generates heat, and a decline in muscle mass and strength can impair the body’s ability to generate and maintain adequate warmth.
D. Decreased subcutaneous fat is a key factor in temperature regulation. Subcutaneous fat acts as an insulator, helping to retain body heat. As people age, they often experience a decrease in subcutaneous fat, which reduces their ability to insulate and maintain body heat effectively.