A client has a new prescription for albuterol (Proventil) to be given by inhalation through a metered-dose inhaler (MDI). Which of the following education should the nurse include?

Choice A rationale

Furosemide is a loop diuretic that acts on the ascending limb of the loop of Henle, not the distal tubule.

Choice B rationale

Spironolactone is a potassium-sparing diuretic that works on the collecting ducts and late distal tubules, not the distal tubule.

Choice C rationale

Mannitol is an osmotic diuretic that acts on the proximal tubule and the descending limb of the loop of Henle, not the distal tubule.

Choice D rationale

Hydrochlorothiazide is a thiazide diuretic that works on the distal convoluted tubule, making it the correct answer.

Choice A rationale

Antagonistic reactions occur when one drug interferes with the action of another, decreasing its effectiveness. This is not applicable in this case as aspirin and alcohol together increase the risk of bleeding rather than opposing each other's actions.

Choice B rationale

Synergistic reactions happen when two drugs enhance each other's effects. Aspirin and alcohol together can indeed increase the risk of gastrointestinal bleeding, but this is not referred to as a synergistic reaction.

Choice C rationale

Additive reactions occur when two drugs with similar effects add up to a greater effect. Aspirin and alcohol both increase the risk of bleeding, and their combined effect leads to gastrointestinal bleeding.

Choice D rationale

Neutral reactions imply that the drugs do not interact and have no combined effect, which is incorrect here as the combination of aspirin and alcohol leads to an increased risk of GI bleeding.