A client's morning laboratory test results include hemoglobin 11.0 g/dL (110 g/L) and hematocrit 34% (0.34 volume fraction). Based on these findings, this client is at risk for which pathophysiological findings?

Reference Ranges:

Hemoglobin [14 to 18 g/dL (140 to 180 g/L)]

Hematocrit [42% to 52% (0.42 to 0.52 volume fraction)]

A) Peripheral neuropathy:

Peripheral neuropathy involves damage to the peripheral nerves and is not directly related to the described crushing injury. While nerve injury can occur as a result of trauma, the signs and symptoms described in the scenario, such as unequal strength between the left and right thighs, are more indicative of a potential vascular or musculoskeletal issue rather than peripheral neuropathy.

B) Osteomyelitis:

Osteomyelitis is a bone infection that can occur secondary to trauma or as a complication of open fractures. While it is possible for a crushing injury to lead to osteomyelitis if there is bone involvement or an open wound, the scenario mentions that x-rays revealed no broken bones. Additionally, the signs and symptoms described, such as bruising and swelling of the thighs, are not specific to osteomyelitis.

C) Fat embolism:

Fat embolism occurs when fat globules enter the bloodstream, often following traumatic injury to long bones or orthopedic procedures. While a crushing injury can theoretically lead to fat embolism, the absence of long bone fractures in the x-rays makes this less likely. Additionally, fat embolism typically presents with respiratory symptoms such as dyspnea and hypoxemia, which are not described in the scenario.

D) Compartment syndrome:

Correct. Compartment syndrome is a serious condition that can occur following a crushing injury, especially in the extremities. It is characterized by increased pressure within a muscle compartment, leading to compromised blood flow and potential tissue damage. Signs and symptoms of compartment syndrome include severe pain, swelling, bruising, decreased or absent pulses, and neurological deficits. The unequal strength between the left and right thighs could indicate neurological deficits due to compromised blood flow or nerve compression, making assessment for signs of compartment syndrome crucial in this client's plan of care. If compartment syndrome is suspected, prompt medical intervention, such as fasciotomy to relieve pressure, may be necessary to prevent complications.

Smoking is a well-established risk factor for lung cancer, and the pathophysiological process underlying this association involves the exposure of the lungs to carcinogenic agents present in tobacco smoke. Here's why option C is the correct choice:

A) Vasoconstrictive properties of nicotine reduce oxygenation and stimulate metabolism:

While nicotine is a primary addictive component of tobacco smoke and can lead to vasoconstriction, reduced oxygenation, and increased metabolism, these effects primarily contribute to cardiovascular diseases associated with smoking, such as coronary artery disease and stroke, rather than the development of lung cancer.

B) Drug addiction changes the neurochemical messages in the brain causing cravings:

This statement addresses the addictive nature of nicotine and its impact on neurochemistry, leading to cravings and dependence. While addiction is a significant aspect of tobacco use, it does not directly explain the pathophysiological process by which smoking causes lung cancer.

C) Carcinogenic agents in tobacco alter cellular cytology, morphology, and function of the lung:

Correct. Tobacco smoke contains numerous carcinogenic compounds, such as polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and benzene, which can directly damage the DNA of lung cells. This DNA damage can lead to mutations and alterations in cellular cytology, morphology, and function, ultimately contributing to the development of lung cancer.

D) Risk for comorbidities increase incidence of chronic diseases and decrease longevity:

While smoking is associated with an increased risk of various comorbidities and chronic diseases, such as cardiovascular diseases, respiratory diseases, and certain cancers, this option does not specifically address the pathophysiological process of lung cancer development.