The nurse is caring for a client who experienced multiple invasive trauma from a motor vehicle collision and has developed systemic inflammatory response syndrome (SIRS). Which pathophysiological process is most likely associated with the development of SIRS in this client?

Multiple organ dysfunction.

Acute kidney injury.

Intestinal obstruction.

Sepsis.

Answer and Explanation

The Correct Answer is A

A) Multiple organ dysfunction:

Correct. Systemic inflammatory response syndrome (SIRS) is a widespread inflammatory response to a variety of severe clinical insults, including trauma, infection, burns, or other sources of tissue injury. In the context of trauma from a motor vehicle collision, the body may mount a systemic inflammatory response involving multiple organ systems. This can progress to multiple organ dysfunction syndrome (MODS), where there is progressive dysfunction of two or more organ systems.

B) Acute kidney injury:

Acute kidney injury (AKI) can certainly occur in the context of severe trauma and systemic inflammation, such as in SIRS. However, AKI is a specific manifestation rather than the overarching pathophysiological process associated with the development of SIRS.

C) Intestinal obstruction:

Intestinal obstruction is a mechanical obstruction of the intestines and is not typically associated with the development of SIRS unless there is associated ischemia or perforation leading to systemic inflammation.

D) Sepsis:

Sepsis is a severe infection that has spread throughout the body and triggers a systemic inflammatory response. While sepsis can lead to SIRS, it is not the only cause. In this scenario, trauma from a motor vehicle collision is the primary cause of the systemic inflammatory response, rather than infection.

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Correct Answer is B

Explanation

Leukotrienes are inflammatory mediators derived from arachidonic acid metabolism, primarily produced by leukocytes (white blood cells) such as mast cells, eosinophils, and basophils. In the context of asthma, leukotrienes play a significant role in the pathophysiology of the disease by contributing to airway inflammation and bronchoconstriction. Here's a breakdown of their immune response:

A) Produce the sensation of itching:

Leukotrienes are not directly involved in producing the sensation of itching. Itching is often associated with histamine release rather than leukotrienes.

B) Tighten airway and produce mucous:

Correct. Leukotrienes are potent bronchoconstrictors that cause smooth muscle contraction in the airways, leading to narrowing (constriction) of the bronchioles. Additionally, they stimulate the secretion of mucus from goblet cells in the airway epithelium, contributing to airway obstruction and mucus production, which are characteristic features of asthma exacerbations.

C) Causes formation of bradykinin:

Bradykinin is a peptide mediator that is generated from the plasma protein kininogen and is involved in vasodilation, pain sensation, and inflammation. Leukotrienes are not directly responsible for the formation of bradykinin.

D) Serves as a receptor for antigen:

Leukotrienes do not serve as receptors for antigens. Instead, they are lipid mediators released in response to various stimuli, including allergens, infections, and irritants, and they act on specific receptors (e.g., leukotriene receptors) to exert their effects, such as bronchoconstriction and inflammation

A. Shivering. B. Purulent drainage. C. Temperature of 102° F (37.8° C). D. Redness and localized heat.

Correct Answer is D

Explanation

A) Shivering:

Shivering is not a normal inflammatory response to wound healing. It may indicate systemic symptoms such as fever or chills, which could be indicative of infection or other complications.

B) Purulent drainage:

Purulent drainage (pus) is often a sign of infection rather than a normal inflammatory response to wound healing. While some serous or serosanguinous drainage may be expected initially, purulent drainage suggests an abnormal response.

C) Temperature of 102° F (37.8° C):

A temperature of 102° F (37.8° C) is indicative of fever, which can occur in response to infection or inflammation. While fever is part of the inflammatory response, it is not necessarily considered a normal finding in the context of wound healing and may indicate an abnormal response such as infection.

D) Redness and localized heat:

Correct. Redness (erythema) and localized heat are typical signs of the inflammatory phase of wound healing. Inflammation is a normal response to tissue injury and is characterized by increased blood flow to the area, resulting in redness and warmth. These signs indicate that the body's immune response is active and working to repair the injured tissue.

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The nurse is caring for a client who experienced multiple invasive trauma from a motor vehicle collision and has developed systemic inflammatory response syndrome (SIRS). Which pathophysiological process is most likely associated with the development of SIRS in this client?

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Naxlex Comprehensive Predictor Exams

A client who has asthma (a reactive airway disease) asks the nurse about the role of leukotrienes in this process. Leukotrienes have which immune response?

Correct Answer is B

Explanation

The nurse assesses the wound of a client who received sutures for a laceration of the hand two days ago. Which finding is a normal inflammatory response?

Correct Answer is D

Explanation

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