A nurse administered ondansetron (Zofran) IV to a client 30 minutes ago. Which of the following findings should the nurse recognize as a complication of this medication?

Prolonged QT interval

Spasms of the neck and face

Nausea

Vomiting

Answer and Explanation

The Correct Answer is A

A.   Ondansetron (Zofran) can cause a prolonged QT interval, which may lead to arrhythmias. This is a known side effect and should be monitored.
B.   Spasms of the neck and face are more likely to occur with medications that have extrapyramidal side effects, such as certain antipsychotics, not ondansetron.
C.   Nausea and D. Vomiting are the symptoms ondansetron is intended to treat, so these are not complications.

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Correct Answer is A

Explanation

A. Oral (PC): Naloxone undergoes rapid first-pass metabolism when taken orally, making it ineffective via this route.
B. Intravenous (IV): This is an effective route for naloxone administration.
C. Intramuscular (IM): This is also an effective route for naloxone administration.
D. Subcutaneous (SC): Naloxone can also be administered subcutaneously.

A. Oral (PO) B. Intravenous (IV) C. Intramuscular (M) D. Subcutaneous (SC)

Correct Answer is A

Explanation

A. The first-pass effect refers to the metabolism of a drug in the liver before it reaches systemic circulation. This primarily affects oral medications, as they are absorbed through the gastrointestinal tract and first pass through the liver.
B. Intravenous (IV) drugs bypass the first-pass effect as they are directly introduced into the bloodstream.
C. Intramuscular (IM) and D. Subcutaneous (SC) routes also bypass the first-pass effect since the drug enters the bloodstream without passing through the liver initially.

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A nurse administered ondansetron (Zofran) IV to a client 30 minutes ago. Which of the following findings should the nurse recognize as a complication of this medication?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer naloxone (Narcan). The nurse understands that this medication has a rapid first-pass inactivation. The nurse understands that naloxone (Narcan) be administered in all of the following routes EXCEPT for:

Correct Answer is A

Explanation

Which of the following routes is affected by the first-pass effect?

Correct Answer is A

Explanation

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