A nurse in an emergency department is assessing a client who has been taking haloperidol for 3 months. The client has a temperature of 39.5* C (103.4° F), blood pressure of 150/110 mm Hg, and muscle rigidity. Which of the following complications should the nurse suspect?

A. Dilute the medication with sterile water before injecting: Phenytoin should not be diluted before administration because it may cause precipitation or crystallization of the drug, leading to potential adverse effects such as tissue irritation or embolism.

B. Administer the medication over 1 min: Phenytoin should be administered slowly over 1 to 2 minutes to reduce the risk of adverse effects such as hypotension or cardiac arrhythmias. Rapid infusion can lead to cardiovascular collapse.

C. Slow the injection if the medication crystallizes: If the medication crystallizes, the nurse should stop the injection immediately and flush the IV line with normal saline. However, preventing crystallization by administering the medication slowly over the recommended time is preferable.

D. Follow the IV injection with sterile water: Following the IV injection with sterile water is not a standard practice for administering phenytoin. Instead, the nurse should follow institutional guidelines for flushing the IV line after medication administration, typically with normal saline.

A. "Do not drink alcohol while taking this medication": Disulfiram is a medication used to deter alcohol consumption by producing unpleasant effects, such as nausea, vomiting, and flushing, if alcohol is consumed. Therefore, it is crucial for the client to abstain from alcohol while taking disulfiram to avoid these adverse reactions.

B. "Do not crush this medication before swallowing": While it is generally important not to alter the formulation of medications unless instructed by a healthcare provider or indicated in the medication's instructions, crushing disulfiram is not typically a concern. However, the primary focus of disulfiram therapy is the avoidance of alcohol, rather than specific administration instructions.

C. "Avoid grapefruit juice while taking this medication": Grapefruit juice is known to interact with certain medications by inhibiting cytochrome P450 enzymes in the liver, affecting drug metabolism. However, there is no significant interaction between disulfiram and grapefruit juice. Therefore, this information is not relevant to disulfiram therapy.

D. "Take this medication with food": Disulfiram is typically taken on an empty stomach, as food can interfere with its absorption. Therefore, advising the client to take disulfiram with food is not accurate and may compromise its effectiveness. The primary concern with disulfiram therapy is adherence to abstinence from alcohol.