A nurse is caring for a client who has Wernicke-Korsakoff psychosis as a result of chronic alcohol use disorder. Which of the following interventions should the nurse anticipate?

A. Pharmacists: Pharmacists are healthcare professionals who are highly knowledgeable about medications, including their indications, dosages, contraindications, interactions, and administration routes. They play a crucial role in ensuring safe medication administration by providing accurate information and counseling to both healthcare providers and patients.

B. Published journals: Published journals contain peer-reviewed articles and research studies on various aspects of medication administration, including best practices, guidelines, new developments, and evidence-based recommendations. Healthcare professionals often refer to reputable journals to stay updated on the latest information and advancements in medication administration.

C. Physicians Desk Reference (PDR): The Physicians Desk Reference is a comprehensive reference book that provides information on prescription drugs, including their indications, dosages, side effects, and interactions. It is commonly used by healthcare providers as a reliable source of medication information to support safe prescribing and administration practices.

D. Pharmaceutical sales representatives: While pharmaceutical sales representatives may provide information about specific medications, their primary role is to promote and market pharmaceutical products. While they may offer valuable information about medication characteristics, their input may be biased toward promoting specific products rather than providing comprehensive and unbiased information about medication administration. Therefore, they are not typically considered acceptable references for safe medication administration.

A. "Do not drink alcohol while taking this medication": Disulfiram is a medication used to deter alcohol consumption by producing unpleasant effects, such as nausea, vomiting, and flushing, if alcohol is consumed. Therefore, it is crucial for the client to abstain from alcohol while taking disulfiram to avoid these adverse reactions.

B. "Do not crush this medication before swallowing": While it is generally important not to alter the formulation of medications unless instructed by a healthcare provider or indicated in the medication's instructions, crushing disulfiram is not typically a concern. However, the primary focus of disulfiram therapy is the avoidance of alcohol, rather than specific administration instructions.

C. "Avoid grapefruit juice while taking this medication": Grapefruit juice is known to interact with certain medications by inhibiting cytochrome P450 enzymes in the liver, affecting drug metabolism. However, there is no significant interaction between disulfiram and grapefruit juice. Therefore, this information is not relevant to disulfiram therapy.

D. "Take this medication with food": Disulfiram is typically taken on an empty stomach, as food can interfere with its absorption. Therefore, advising the client to take disulfiram with food is not accurate and may compromise its effectiveness. The primary concern with disulfiram therapy is adherence to abstinence from alcohol.