A nurse is assessing a client who has received oxycodone. The nurse notes that the client's respiratory rate is 8/min. The nurse should identify that which of the following is the pathophysiology for the client's respiratory rate?

A) Hypertension: Amiodarone is not typically associated with hypertension. Instead, it is more commonly associated with hypotension.

B) Bradypnea: Amiodarone is not typically associated with bradypnea. Instead, it is more commonly associated with pulmonary toxicity, which can manifest as cough, dyspnea, and pulmonary fibrosis.

C) Fever: While fever is a possible adverse effect of amiodarone, it is not one of the most commonly observed adverse effects. Other adverse effects, such as thyroid dysfunction, pulmonary toxicity, and hepatic toxicity, are more frequently reported.

D) Bradycardia: This is the correct answer. Amiodarone is known to cause bradycardia as an adverse effect. It has a negative chronotropic effect, meaning it can slow down the heart rate. Bradycardia is one of the most commonly observed adverse effects of amiodarone and can be significant, particularly in individuals with pre-existing sinus node dysfunction or conduction abnormalities.

D) Calcium: Calcium supplements can interfere with the absorption of levothyroxine when taken concurrently. Levothyroxine absorption can be significantly reduced if taken with calcium-containing supplements or foods high in calcium. Therefore, clients should wait at least 4 hours after taking levothyroxine before consuming calcium supplements to ensure optimal absorption of the thyroid medication.

A) Zinc: Zinc supplements do not significantly interfere with the absorption of levothyroxine. While zinc can bind to levothyroxine and potentially decrease its absorption, the effect is minimal compared to calcium. However, it is generally recommended to take zinc supplements at least 4 hours apart from levothyroxine to avoid any potential interaction.

B) Vitamin C: Vitamin C supplements do not interfere with the absorption of levothyroxine and can be taken concurrently without significant interactions. There is no need for clients to wait a specific amount of time between taking levothyroxine and vitamin C supplements.

C) Ginkgo biloba: Ginkgo biloba supplements have not been shown to have a significant impact on the absorption of levothyroxine. However, given the variability in individual responses to supplements, it is still prudent to separate the administration of levothyroxine and ginkgo biloba by at least 4 hours to minimize any potential interactions.