A nurse is caring for a client who is prescribed diphenhydramine to relieve pruritus. The client asks the nurse how he can minimize the daytime sedation he is experiencing. Which of the following responses should the nurse give?
"Distribute the doses evenly throughout the day!"
"Gradually decrease the dose once tolerance to the effect is reached."
"Take the medication with meals."
"Take most of the daily dose at bedtime."
The Correct Answer is D
Diphenhydramine is an antihistamine medication that can cause sedation as a side effect. Taking most of the daily dose at bedtime can help minimize daytime sedation. By taking the medication closer to bedtime, the sedative effects are more likely to occur during sleep, reducing the impact of sedation during waking hours.
The other options mentioned are not effective strategies to minimize daytime sedation caused by diphenhydramine:
A. "Distribute the doses evenly throughout the day": This approach may lead to a consistent level of sedation throughout the day and may not effectively minimize daytime sedation.
B. "Gradually decrease the dose once tolerance to the effect is reached": Gradually decreasing the dose of diphenhydramine is not a recommended strategy for minimizing daytime sedation. It is important to follow the prescribed dose and consult with a healthcare provider before making any changes to the medication regimen.
C. "Take the medication with meals": Taking diphenhydramine with meals may help reduce the risk of stomach upset but does not directly address the issue of daytime sedation.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Acetaminophen is a commonly used over-the-counter pain reliever and fever reducer. One of the potential adverse reactions to acetaminophen is liver toxicity, which can present with symptoms such as jaundice (yellowing of the skin and eyes), dark urine, and pale stools. It is important for the client to be aware of these signs and symptoms and report them to their healthcare provider if they occur. Monitoring for jaundice can help identify any potential liver-related complications associated with acetaminophen use.
The other options provided in the question are not typically associated with acetaminophen use:
- Tinnitus: Tinnitus refers to a perception of ringing or buzzing in the ears. It is not a commonly reported adverse reaction to acetaminophen.
- Hyperglycemia: Hyperglycemia refers to high blood sugar levels. Acetaminophen does not typically cause hyperglycemia as a side effect.
- Muscle pain: Acetaminophen is used to relieve mild to moderate pain, including muscle pain. It is not an adverse reaction to the medication.

Correct Answer is C
Explanation
Acetaminophen is generally considered safe and well-tolerated when used appropriately. However, it is primarily metabolized by the liver, and in cases of severe hepatic impairment or liver failure, the metabolism of acetaminophen can be significantly impaired. This can lead to the accumulation of toxic metabolites, which can cause further liver damage and potentially result in hepatotoxicity.
Hypertension, gallbladder disease, and tachyarrhythmias are not typically considered contraindications for the use of acetaminophen. However, it is important to consider any potential interactions or precautions when using acetaminophen in patients with these conditions, and consulting with a healthcare provider is recommended to ensure the safe and appropriate use of the medication.

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