A nurse is caring for a client with a new order for acetaminophen.
What of the following options is a therapeutic use of this medication?

Choice A rationale

Spironolactone is a potassium-sparing diuretic that acts on the collecting ducts and late distal tubules but not on the loop of Henle.

Choice B rationale

Hydrochlorothiazide is a thiazide diuretic that works on the distal convoluted tubule, not the loop of Henle.

Choice C rationale

Furosemide is a loop diuretic that acts on the ascending limb of the loop of Henle to inhibit sodium and chloride reabsorption, leading to increased urine output.

Choice D rationale

Mannitol is an osmotic diuretic that primarily acts on the proximal tubule and the descending limb of the loop of Henle.

Choice A rationale

Combining multiple hepatotoxic medications increases the risk of liver damage due to cumulative toxicity effects.

Choice B rationale

Liver damage impairs the liver's ability to metabolize medications, leading to medication accumulation and potential adverse effects.

Choice C rationale

Combining hepatotoxic medications does not decrease the risk of liver damage; it increases it, as multiple toxic agents compound the stress on the liver.

Choice D rationale

Common manifestations of hepatotoxicity include symptoms like nausea, vomiting, jaundice, dark urine, abdominal discomfort, and anorexia, indicating liver dysfunction.