A nurse is providing teaching to a client who is to start taking valproic acid. Which of the following instructions should the nurse include?
You should undergo thyroid function tests every 6 months while taking valproic acid
You should expect the provider to gradually decrease your dosage of valproic acid
You should take aspirin for pain you have while taking valproic acid
You should have your liver function levels monitored regularly while taking valproic acid
The Correct Answer is D
Choice A reason: Valproic acid does not typically require thyroid function tests, as it primarily affects liver metabolism via glucuronidation and mitochondrial pathways. Thyroid dysfunction is not a common side effect, unlike with lithium, which impacts thyroid hormone synthesis. This instruction is irrelevant, as valproic acid’s toxicity risks are hepatic, not thyroid-related.
Choice B reason: Expecting a gradual decrease in valproic acid dosage is incorrect, as it is titrated to therapeutic levels for conditions like seizures or bipolar disorder, based on serum levels (50–100 mcg/mL). Dosage adjustments depend on efficacy, not routine reduction, as stable neural excitability is needed, making this scientifically inaccurate.
Choice C reason: Taking aspirin for pain with valproic acid is risky, as both inhibit platelet function, increasing bleeding risk via synergistic effects on prostaglandin synthesis. Valproic acid’s hepatic metabolism also raises hepatotoxicity concerns, making aspirin inappropriate. Alternative analgesics like acetaminophen are safer, rendering this instruction incorrect.
Choice D reason: Valproic acid requires regular liver function monitoring, as it is hepatically metabolized and can cause hepatotoxicity, particularly in the first 6 months, due to mitochondrial dysfunction and oxidative stress. Elevated liver enzymes or rare fulminant hepatitis necessitate early detection to prevent liver failure, making this a critical instruction.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A reason: The belief that clients who talk about suicide are less likely to attempt it is a myth. Verbalizing suicidal ideation often reflects severe distress and heightened risk, as it may indicate prefrontal cortex dysfunction and impaired impulse control. This misconception underestimates the neurobiological basis of suicidal behavior, requiring vigilant assessment.
Choice B reason: Assuming clients who fail a suicide attempt will not try again is incorrect. Previous attempts increase future risk, as suicidal behavior is linked to persistent psychological distress and serotonin dysregulation. This assumption ignores the chronicity of underlying conditions like depression, necessitating ongoing monitoring and intervention to prevent recurrence.
Choice C reason: Claiming failed suicide attempts indicate a lack of intent to die is false. Many attempts fail due to external factors, not lack of intent. Suicidal behavior reflects complex neurobiological factors, including serotonin imbalance and prefrontal cortex deficits, requiring serious intervention regardless of outcome, as intent persists in high-risk individuals.
Choice D reason: A specific suicide plan indicates high risk, as it reflects advanced ideation and intent, often linked to prefrontal cortex dysfunction and reduced impulse control. Detailed planning suggests the client has visualized the act, increasing likelihood of completion. This principle guides nursing care to prioritize safety and immediate psychiatric intervention.
Correct Answer is C
Explanation
Choice A reason: Responding positively to flattery risks reinforcing manipulative behavior and does not address potential underlying distress. The client’s statement may reflect emotional dysregulation or suicidal ideation, common in psychiatric conditions with serotonin imbalances. This response fails to probe for serious neurobiological risks, missing a critical assessment opportunity.
Choice B reason: Assuming the client wants something is confrontational and dismissive, ignoring potential suicidal ideation or emotional distress. The statement may reflect serotonin-driven mood instability or a cry for help, requiring sensitive exploration. This response risks alienating the client, missing neurobiological cues for underlying psychiatric concerns.
Choice C reason: Asking about suicidal thoughts is appropriate, as the client’s statement may signal ideation, linked to serotonin dysregulation and prefrontal cortex deficits. Such expressions can indicate despair or intent in psychiatric conditions, necessitating direct assessment to ensure safety and address potential neurobiological imbalances driving suicidal behavior.
Choice D reason: Dismissing the statement as insincere ignores potential distress signals, such as suicidal ideation or emotional dysregulation from serotonin imbalances. This response fails to engage the client’s underlying neurobiological state, risking missed opportunities to assess serious psychiatric concerns and provide appropriate intervention or support.
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