A nurse is reviewing the laboratory data of a client who is receiving filgrastim. Which of the following laboratory values should the nurse monitor to evaluate the effectiveness of the treatment?

INR

Potassium level

WBC count

BUN

Answer and Explanation

The Correct Answer is C

A. INR (International Normalized Ratio): INR is a measure of blood clotting and is not directly affected by filgrastim, which stimulates the production of white blood cells. Monitoring INR is more relevant when assessing anticoagulant therapy.
B. Potassium level: Filgrastim does not directly influence potassium levels. Monitoring potassium is important for certain medications and conditions, but it is not the primary parameter to evaluate the effectiveness of filgrastim.
C. WBC count: Filgrastim (granulocyte colony-stimulating factor) is used to stimulate the production of white blood cells, specifically neutrophils. Monitoring the white blood cell count is crucial in evaluating the effectiveness of filgrastim treatment. An increase in the WBC count, particularly the neutrophil count, indicates a positive response to the medication.
D. BUN (Blood Urea Nitrogen): BUN is a measure of kidney function and is not directly influenced by filgrastim. While monitoring kidney function is important in general patient care, it is not the primary parameter to assess the effectiveness of filgrastim.

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Correct Answer is C

Explanation

A.PT (Prothrombin Time) 11 seconds: The prothrombin time measures the extrinsic pathway of the coagulation cascade. A PT of 11 seconds is within the normal range, and it indicates that the extrinsic clotting pathway is functioning appropriately. There is no need to report this value.
B. APTT (Activated Partial Thromboplastin Time) 50 seconds: The APTT measures the intrinsic pathway of the coagulation cascade. A value of 50 seconds is prolonged and may suggest that the client is receiving an effective anticoagulant dose. However, the APTT target range can vary based on the specific therapeutic goal and the heparin protocol in use. It's essential to follow the healthcare provider's guidance on the target APTT range.
C. Hematocrit 456: The normal range for hematocrit is usually expressed as a percentage. A value of 456 is outside the normal range and likely represents an error or a misinterpretation. The nurse should verify this value, as an extremely high hematocrit could be indicative of an issue such as dehydration or an analytical error.
D. Platelets 300,000/mm²: A platelet count of 300,000/mm² is within the normal range. There is no need to report this value as it suggests a normal platelet count.

A. Decrease in urine output B. Increase in serum glucose C. Increase in WBC count D. Decrease in blood pressure

Correct Answer is A

Explanation

A. Decrease in urine output:
This is the correct answer. Desmopressin is a synthetic form of antidiuretic hormone (ADH) that works to reduce urine output in individuals with diabetes insipidus. A decrease in urine output indicates a positive response to the medication.
B. Increase in serum glucose:
Desmopressin does not have a direct effect on serum glucose levels. Its primary action is to increase water reabsorption in the kidneys, reducing urine output.
C. Increase in WBC count:
Desmopressin does not have a direct impact on white blood cell (WBC) count. Its main action is on fluid balance and urine concentration.
D. Decrease in blood pressure:
Desmopressin can cause a mild increase in blood pressure, particularly at higher doses. However, blood pressure changes are not the primary therapeutic effect of desmopressin in the context of diabetes insipidus.

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A nurse is reviewing the laboratory data of a client who is receiving filgrastim. Which of the following laboratory values should the nurse monitor to evaluate the effectiveness of the treatment?

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