A nurse is reviewing the list of current medications for a client who is to start a new prescription for carbamazepine.
The nurse should identify which of the following medications interacts with carbamazepine?

Raloxifene is a medication used to prevent and treat osteoporosis in postmenopausal women.

Osteoporosis is a condition that causes bones to become thin and weak, increasing the risk of fractures.

Raloxifene belongs to a class of drugs called selective estrogen receptor modulators (SERMs), which mimic the effects of estrogen on bone density. Choice B is wrong because raloxifene may increase the risk of deep-vein thrombosis (DVT), a type of blood clot that forms in a vein deep in the body. DVT can cause pain, swelling, and redness in the affected limb, and can lead to serious complications such as pulmonary embolism (PE), a blood clot in the lung.

Raloxifene should not be used by people who have or had DVT or PE. Choice C is wrong because raloxifene is not used to treat urinary tract infection (UTI), an infection that affects the bladder, kidneys, or ureters. UTI can cause symptoms such as burning or pain when urinating, frequent or urgent urination, blood in the urine, or fever.

UTI is usually treated with antibiotics.

Choice D is wrong because raloxifene is not used to treat hypothyroidism, a condition that occurs when the thyroid gland does not produce enough thyroid hormone.

Thyroid hormone regulates the body’s metabolism, growth, and development. Hypothyroidism can cause symptoms such as fatigue, weight gain, cold intolerance, dry skin, hair loss, or depression.

Hypothyroidism is usually treated with synthetic thyroid hormone replacement.

This is because TB is caused by a bacterium that can develop resistance to single-drug therapy, so a combination of drugs is used to prevent or treat drug-resistant strains. Some of the common drugs used for TB are isoniazid, rifampin, ethambutol, and pyrazinamide.

Choice A is wrong because the duration of treatment for active TB is usually 6 to 9 months, not 3 years.

Choice B is wrong because tuberculin skin tests are not reliable indicators of disease activity or response to treatment, as they can remain positive for years after successful therapy.

Choice C is wrong because blood tests to monitor kidney function are not routinely required for TB treatment unless the client has a preexisting renal impairment or is taking drugs that are nephrotoxic.