A nurse is reviewing the phases of pharmacokinetics. Which of the following phases is the change of a drug into a less or more potent or more soluble form after it passes through the liver?
Excretion
Absorption
Distribution
Metabolism
The Correct Answer is D
A. Excretion is the removal of the drug from the body, typically through the kidneys, and is not related to changes in the drug's potency or solubility.
B. Absorption is the process of the drug entering the bloodstream, not a process that alters the drug's chemical form.
C. Distribution is the process by which the drug is spread throughout the body’s tissues and organs, not
the phase where the drug is altered.
D. Metabolism, primarily occurring in the liver, involves the conversion of drugs into more water-soluble forms, which can either increase or decrease their potency.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A. This statement is incorrect because spironolactone is not a loop diuretic and does not act in the loop of Henle. It works in the distal tubules of the kidney.
B. This description is more accurate for thiazide diuretics. Spironolactone works as an aldosterone antagonist and primarily affects sodium and water retention.
C. This description applies to osmotic diuretics like mannitol, not spironolactone.
D. Spironolactone is a potassium-sparing diuretic that works by blocking aldosterone, preventing sodium and water retention, while promoting the retention of potassium.
Correct Answer is ["A","B","D"]
Explanation
A. Metformin interacts with iodine-containing contrast dye, increasing the risk of acute renal failure. Clients should temporarily stop metformin before undergoing contrast procedures.
B. Metformin is available in an oral form and is commonly prescribed for type 2 diabetes.
C. Weight gain is not a common side effect of metformin; in fact, it is often associated with weight neutrality or mild weight loss.
D. Metformin is typically used as a first-line medication for managing type 2 diabetes.
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