A nurse is teaching a group of student nurses about populations at higher risk for multiple sclerosis. Which of the following demographics should be included in the teaching?
(Select All that Apply.)

Choice A Reason:

Decreased blood pressure is correct. Decreased blood pressure (hypotension) is the priority finding to monitor for because it is indicative of a severe allergic reaction known as anaphylaxis. Anaphylaxis is a potentially life-threatening condition that can lead to shock, organ failure, and death if not promptly treated. Hypotension in the context of an allergic reaction suggests widespread vasodilation and increased vascular permeability, resulting in a decrease in blood pressure.

Choice B Reason:

Stomach pain is incorrect. Stomach pain may indicate gastrointestinal distress or adverse effects of the antibiotic, but it is not typically as immediately life-threatening as decreased blood pressure in the context of anaphylaxis. While abdominal pain should not be ignored, it is not the priority finding when assessing for signs of anaphylaxis.

Choice C Reason:

Urticaria is incorrect. Urticaria, also known as hives, is a common allergic reaction characterized by raised, itchy welts on the skin. While urticaria can be uncomfortable and distressing, it is not immediately life-threatening. However, urticaria may be a precursor to more severe allergic reactions, such as anaphylaxis, so it is still important to monitor closely.

Choice D Reason:

Lightheadedness is incorrect. Lightheadedness may occur as a result of hypotension in the context of anaphylaxis, but it is not as critical as directly monitoring blood pressure. Lightheadedness may also be caused by other factors, such as anxiety or dehydration, and may not always indicate a severe allergic reaction. While it is important to assess for lightheadedness and monitor the client's overall condition, it is not the priority finding compared to decreased blood pressure.

Choice A Reason:

Genetics is correct. There is evidence to suggest that genetics play a role in the development of multiple sclerosis. Although no single gene has been identified as the cause of MS, certain genetic variations have been associated with an increased risk of developing the disease. Having a first-degree relative with MS increases an individual's risk, although the overall genetic contribution to MS susceptibility is thought to be relatively modest.

Choice B Reason:

Environmental factors is correct. Environmental factors are believed to play a significant role in the development of multiple sclerosis, particularly in individuals with a genetic predisposition. Factors such as vitamin D deficiency, smoking, exposure to certain infections (such as Epstein-Barr virus), and geographic location (latitude) have been implicated as potential triggers for MS development.

Choice C Reason:

Upper respiratory infections is incorrect. While infections may trigger exacerbations or relapses in individuals with existing multiple sclerosis, there is limited evidence to suggest that upper respiratory infections contribute directly to the development of MS. However, some research suggests that viral infections, particularly those occurring during childhood or adolescence, may influence the risk of developing MS later in life.

Choice D Reason:

Autoimmune factors is correct. Multiple sclerosis is widely recognized as an autoimmune disease, characterized by immune-mediated inflammation and damage to the central nervous system. In MS, the immune system mistakenly attacks myelin, the protective covering of nerve fibers, leading to demyelination and neurological dysfunction. Autoimmune factors are therefore considered central to the pathogenesis of MS.

Choice E Reason:

Urinary tract infections is incorrect. While urinary tract infections (UTIs) are common in individuals with multiple sclerosis due to bladder dysfunction associated with the disease, there is no direct evidence to suggest that UTIs contribute to the development of MS.