A nurse is teaching a patient about a medication that alters sympathetic nervous system functions. To evaluate understanding, the nurse asks the patient to describe which functions the sympathetic nervous system regulates. Which answer indicates the need for further teaching?

Choice A Reason:

Clinical trials to assess the teratogenic effects of medications during pregnancy are ethically challenging because they would involve exposing pregnant women and their fetuses to potential risks. The primary concern is the safety of the fetus, as many drugs can cross the placenta and potentially cause harm. Therefore, most of the data on teratogenic effects come from observational studies, case reports, and animal studies rather than controlled clinical trials.

Choice B Reason:

While the FDA has initiatives to improve the safety of medications during pregnancy, it is not accurate to say that a new study will allow testing of medications during pregnancy in the future. The ethical concerns surrounding the exposure of pregnant women to potential teratogens remain a significant barrier. Current efforts focus on improving post-marketing surveillance and encouraging the reporting of adverse effects to gather more data.

Choice C Reason:

Although some women may be reluctant to admit taking medications during pregnancy, this is not the primary reason for the lack of data on teratogenic effects. The main issue is the ethical and practical challenges of conducting clinical trials in pregnant women. Reluctance to report medication use can contribute to underreporting, but it is not the central factor.

Choice D Reason:

Recommending that pregnant women avoid medications is a general precaution, but it does not address the reason why more is not known about teratogenic effects. The avoidance of medications is advised to minimize potential risks, but the lack of data is primarily due to the ethical constraints of conducting clinical trials in this population.

Choice A Reason:

Chronic stress can significantly impact mental health, leading to conditions such as depression. The persistent activation of the stress response system, particularly the release of cortisol, can alter brain function and structure, contributing to mood disorders. Studies have shown that prolonged exposure to stress hormones can lead to changes in the brain that are associated with depression.

Choice B Reason:

Impaired cognitive function is another consequence of chronic stress. Elevated levels of cortisol over an extended period can damage the hippocampus, a region of the brain involved in memory and learning. This can result in difficulties with concentration, memory, and decision-making. Chronic stress has been linked to cognitive decline and an increased risk of neurodegenerative diseases.

Choice C Reason:

Chronic stress can also affect the immune system, leading to autoimmune diseases. The continuous activation of the stress response can cause immune dysregulation, where the body’s immune system mistakenly attacks its own tissues. This can result in conditions such as rheumatoid arthritis, lupus, and other autoimmune disorders.

Choice D Reason:

Overactive immune function is not typically associated with chronic stress. Instead, chronic stress often leads to a weakened immune response, making the body more susceptible to infections and illnesses. Therefore, this choice is incorrect.

Choice E Reason:

Cardiovascular disease is a well-documented consequence of chronic stress. The persistent release of stress hormones like adrenaline and cortisol can lead to increased blood pressure, heart rate, and the formation of artery-clogging deposits. These changes can increase the risk of heart disease, heart attacks, and strokes.