Which type of cell death causes the least damage to cells that are nearby?
Atrophy
Apoptosis
Necrosis
Lysis
The Correct Answer is B
Choice A Reason:
Atrophy refers to the reduction in size or wasting away of an organ or tissue due to a decrease in cell size or number. It is not a type of cell death but rather a process of cell shrinkage and loss of function. Therefore, it does not directly relate to the damage caused to nearby cells.
Choice B Reason:
This is the correct answer. Apoptosis is a form of programmed cell death that occurs in a controlled and regulated manner. It allows for the removal of damaged or unnecessary cells without causing an inflammatory response or damage to surrounding tissues. During apoptosis, cellular components are neatly packaged into vesicles called apoptotic bodies, which are then phagocytosed by neighboring cells or immune cells, preventing the release of harmful substances.
Choice C Reason:
Necrosis is a form of traumatic cell death that results from acute cellular injury. It often leads to the uncontrolled release of cellular contents, causing inflammation and damage to surrounding tissues. This process can be detrimental to nearby cells and is generally considered more harmful than apoptosis.
Choice D Reason:
Lysis refers to the breaking down or destruction of cells, often due to external factors such as toxins, infections, or immune responses. Like necrosis, lysis can result in the release of cellular contents into the surrounding environment, leading to inflammation and damage to nearby cells.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A Reason:
Oxygenation of the cells is a necessary process during reperfusion, but it is not the direct cause of reperfusion injury. The injury occurs due to the sudden influx of oxygen, which leads to the formation of reactive oxygen species (ROS) or free radicals. These free radicals cause oxidative stress and damage to the myocardial cells.
Choice B Reason:
Free radical formation is the primary mechanism behind reperfusion injury. When blood flow is restored to the ischemic myocardium, the sudden reintroduction of oxygen leads to the production of free radicals. These free radicals cause significant oxidative damage to the cell membranes, proteins, and DNA, exacerbating the injury to the heart tissue.
Choice C Reason:
An increased metabolic state can occur during reperfusion as the cells attempt to recover from ischemia. However, it is not the direct cause of reperfusion injury. The primary issue is the oxidative stress caused by free radicals, not the metabolic changes themselves.
Choice D Reason:
Lactic acid build-up is a consequence of anaerobic metabolism during the ischemic period, not a cause of reperfusion injury. During ischemia, cells switch to anaerobic metabolism, leading to lactic acid accumulation. However, once oxygen is reintroduced, the focus shifts to the oxidative damage caused by free radicals rather than lactic acid.

Correct Answer is A
Explanation
Choice A Reason:
Norepinephrine is a key neurotransmitter released by the sympathetic nervous system during the “fight-or-flight” response. It plays a crucial role in preparing the body to respond to stress by increasing heart rate, blood pressure, and blood flow to muscles, as well as dilating the airways. These physiological changes are essential for coping with acute stress.
Choice B Reason:
Cortisol is a hormone released by the adrenal glands in response to stress, but it is primarily associated with the hypothalamic-pituitary-adrenal (HPA) axis rather than the sympathetic nervous system. While cortisol contributes to the body’s overall stress response by increasing blood sugar levels and suppressing the immune system, it is not the primary mediator of the acute “fight-or-flight” response.
Choice C Reason:
ACTH (adrenocorticotropic hormone) is a hormone produced by the pituitary gland that stimulates the adrenal glands to release cortisol. It is part of the HPA axis and plays a role in the body’s long-term stress response, but it is not directly involved in the immediate activation of the sympathetic nervous system.
Choice D Reason:
Glucagon is a hormone produced by the pancreas that raises blood glucose levels by promoting the breakdown of glycogen to glucose in the liver. While it can be involved in the body’s response to stress by ensuring an adequate supply of glucose, it is not a primary mediator of the acute stress response mediated by the sympathetic nervous system.
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