A patient is admitted for acute renal failure and the nurse is monitoring their response to medications. Which pharmacokinetic principle does the nurse understand will most likely be affected in this patient?

Elimination

Metabolism

Distribution

Absorption

Answer and Explanation

The Correct Answer is A

Choice A reason: Elimination is the process of removing a drug from the body, usually through the kidneys or the liver. Acute renal failure is a condition where the kidneys suddenly lose their ability to filter waste products and excess fluid from the blood. This can impair the elimination of drugs that are mainly excreted by the kidneys, leading to increased drug levels and potential toxicity. The nurse should monitor the patient's renal function and adjust the dose of drugs that are renally eliminated.

Choice B reason: Metabolism is the process of transforming a drug into one or more metabolites, usually by enzymes in the liver. Acute renal failure does not directly affect the metabolism of drugs, unless it causes liver damage or alters the blood flow to the liver. The nurse should monitor the patient's liver function and the levels of drugs that are metabolized by the liver.

Choice C reason: Distribution is the process of transferring a drug from the blood to the tissues and organs of the body. Acute renal failure can affect the distribution of drugs that are bound to plasma proteins, such as albumin. When the kidneys are damaged, they may leak protein into the urine, causing hypoalbuminemia (low levels of albumin in the blood). This can increase the amount of free or unbound drug in the blood, which may enhance the drug's effect or cause adverse reactions. The nurse should monitor the patient's serum albumin level and the effects of drugs that are highly protein bound.

Choice D reason: Absorption is the process of moving a drug from the site of administration to the bloodstream. Acute renal failure does not directly affect the absorption of drugs, unless it causes changes in the gastrointestinal tract, such as edema, bleeding, or motility disorders. The nurse should monitor the patient's gastrointestinal function and the bioavailability of drugs that are administered orally.

Nursing Test Bank

Quiz #1: RN Exams Pharmacology Exams Quiz #2: RN Exams Medical-Surgical Exams Quiz #3: RN Exams Fundamentals Exams Quiz #4: RN Exams Maternal-Newborn Exams Quiz #5: RN Exams Anatomy and Physiology Exams Quiz #6: RN Exams Obstetrics and Pediatrics Exams Quiz #7: RN Exams Fluid and Electrolytes Exams Quiz #8: RN Exams Community Health Exams Quiz #9: RN Exams Promoting Health across the lifespan Exams Quiz #10: RN Exams Multidimensional care Exams

Get 100+ Naxlex Exit Exams for $79 Try Naxlex NCLEX-RN (14 Day Free-Trial)

Naxlex Comprehensive Predictor Exams

Quiz #1: Naxlex RN Comprehensive online practice 2019 B with NGN Quiz #2: Naxlex RN Comprehensive Predictor 2023 Quiz #3: Naxlex RN Comprehensive Predictor 2023 Exit Exam A Quiz #4: Naxlex HESI Exit LPN Exam Quiz #5: Naxlex PN Comprehensive Predictor PN 2020 Quiz #6: Naxlex VATI PN Comprehensive Predictor 2020 Quiz #8: Naxlex PN Comprehensive Predictor 2023 - Exam 1 Quiz #10: Naxlex HESI PN Exit exam Quiz #11: Naxlex HESI PN EXIT Exam 2

Free Nursing Study Resources

Correct Answer is ["A","B"]

Explanation

Choice A reason: Age is a non-modifiable risk factor for hypertension because the risk of high blood pressure increases as we get older. This is due to changes in the heart and blood vessels, such as loss of elasticity and stiffening of the arteries, that affect the blood flow and pressure. ¹

Choice B reason: Genetics is a non-modifiable risk factor for hypertension because some people inherit genes that make them more likely to develop high blood pressure. For example, people of African and Black Caribbean descent have a higher risk of hypertension due to genetic variations that affect salt sensitivity and blood vessel function. ²

Choice C reason: Smoking is a modifiable risk factor for hypertension because it can be changed or avoided by quitting tobacco use. Smoking damages the blood vessels and increases the risk of atherosclerosis, which is the buildup of plaque in the arteries that narrows them and raises blood pressure. Smoking also lowers the level of good cholesterol (HDL) and raises the level of bad cholesterol (LDL) and triglycerides, which are fats in the blood that contribute to plaque formation. ³

Choice D reason: Obesity is a modifiable risk factor for hypertension because it can be changed or prevented by losing weight or maintaining a healthy weight. Obesity increases the risk of high blood pressure by putting extra strain on the heart and blood vessels, as well as by causing hormonal and metabolic changes that affect blood pressure regulation. Obesity is also associated with other conditions that can raise blood pressure, such as diabetes, sleep apnea, and kidney disease. ⁴

Choice E reason: Sedentary lifestyle is a modifiable risk factor for hypertension because it can be changed or improved by increasing physical activity. Sedentary lifestyle increases the risk of high blood pressure by reducing the ability of the blood vessels to dilate and contract, as well as by increasing the risk of obesity, diabetes, and high cholesterol. Physical activity helps to lower blood pressure by improving blood flow, strengthening the heart muscle, and lowering body weight and stress levels. .

A. No answer is provided B. 1 C. No answer is too low D. No answer is too high E. No answer is too high

Correct Answer is B

Explanation

This choice is correct because it is the result of dividing the ordered dose (0.25 mg) by the strength of the tablet (250 mcg or 0.25 mg). The formula for calculating the number of tablets to be given is:

Tablets = Dose/ Strength

Therefore, the number of tablets to be given is:

Tablets = 0.25 mg/250 mcg = 0.25 mg/0.25 mg = 1

View Question and Answer

Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.

Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today

A patient is admitted for acute renal failure and the nurse is monitoring their response to medications. Which pharmacokinetic principle does the nurse understand will most likely be affected in this patient?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The nurse would recognize which of the following as non-modifiable risk factors for hypertension? SELECT ALL THAT APPLY

Correct Answer is ["A","B"]

Explanation

Order: Digoxin 0.25 mg On hand: 250 mcg tablets How many tablets will the nurse give?

Correct Answer is B

Explanation

A nurse is obtaining a medication history from a client who reports taking 1 oz of magnesium hydroxide daily as a laxative. The nurse should identify that this dose equates to how many mL? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

A nurse is preparing to administer hydrocortisone 150 mg via IV bolus. Available is hydrocortisone 50 mg/mL. How many mL should the nurse administer? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

Order: Metoprolol 3.5 mg IV push On hand: 1 mg/mL vials How many milliliters will the nurse draw up to administer this dose?

Which of the following clients would the nurse question an order for labetalol 50 mg PO?

A nurse is preparing to administer 0.45% sodium chloride 2.5 L IV to infuse over 24 hr. How many mL should the nurse administer? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

A 27 year old female client has a new prescription for captopril. What will the nurse be sure to include in the patient teaching?

A nurse is preparing to administer voriconazole 6 mg/kg via intermittent IV bolus to a client who weighs 127 lb. Available is voriconazole 5 mg/mL. How many mL should the nurse administer? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

A nurse is preparing to administer enoxaparin 40 mg subcutaneous for prevention of deep vein thrombosis. Available is enoxaparin 100 mg/mL. How many mL should the nurse administer? (Round the answer to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.)