A patient is being admitted to the floor following a motor vehicle accident. because of the stressful nature of the event, the nurse anticipates the patient will continue to have a sympathetic reaction during the post operative period. When monitoring the patient's serum electrolytes, what will the nurse closely monitor?

A) Suspect worsening of the anxiety disorder:
While it is possible that the patient's anxiety disorder is worsening, the more likely explanation for the reduced effectiveness of lorazepam is the development of drug tolerance. Over time, patients may require higher doses of a medication to achieve the same therapeutic effect, especially with medications like lorazepam that are used chronically.

B) Contact the provider to discuss changing to another benzodiazepine:
Changing to another benzodiazepine might be an option, but it is more likely that tolerance to lorazepam is the cause of the reduced effect, not an issue with the specific drug. Tolerance is common with long-term use of benzodiazepines, and switching drugs may not address the underlying issue. The first step would be to assess the current medication regimen and discuss possible adjustments with the provider.

C) Understand that the patient has developed tolerance to this drug:
Tolerance occurs when the body becomes accustomed to the effects of a medication over time, requiring higher doses to achieve the same therapeutic effect. This is a common phenomenon with benzodiazepines like lorazepam, which are often used for long periods to manage anxiety. As the patient has been taking lorazepam for six months, this reduced effectiveness is likely due to the development of tolerance, rather than a worsening of the anxiety disorder.

D) Notify the provider and discuss increasing the dose of lorazepam:
While increasing the dose of lorazepam could temporarily relieve symptoms, it is not the most appropriate first step. The nurse should first consider the possibility of tolerance and discuss this with the provider before increasing the dose. Long-term increases in benzodiazepine dosages can increase the risk of side effects, dependency, and withdrawal symptoms.

A) CSF proteins and an angiography: While cerebrospinal fluid (CSF) analysis is a valuable diagnostic tool in multiple sclerosis (MS), angiography is not typically used in diagnosing MS. Angiography is primarily used to assess blood vessels and would not help in diagnosing a neurological condition like MS, which involves the central nervous system's myelin sheath.
B) Serum anti-acetylcholine antibodies and x-rays: Anti-acetylcholine antibodies are more relevant for diagnosing autoimmune conditions such as myasthenia gravis, not multiple sclerosis. Additionally, x-rays are not useful for diagnosing MS, as MS is primarily a disorder of the central nervous system, and x-rays are not effective in visualizing soft tissues or brain lesions associated with MS.
C) Serum albumin and a computed tomography (CT) scan: Serum albumin levels are not relevant for diagnosing MS. A CT scan may be used in some cases to rule out other conditions, but magnetic resonance imaging (MRI) is more sensitive and specific for diagnosing MS. MRI is particularly effective in detecting the plaques or lesions in the brain and spinal cord that are characteristic of MS.
D) Cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI): This is the correct combination of diagnostic tests for multiple sclerosis. CSF analysis can show elevated levels of immunoglobulin G (IgG) and oligoclonal bands, which are common in MS. MRI is the most sensitive imaging tool for detecting the characteristic plaques or demyelinated areas in the brain and spinal cord, which are hallmarks of MS. Therefore, this combination is the gold standard for confirming the diagnosis of MS.