Determine the flow rate in mL per hour for the following IV being administered by infusion pump: Ampicillin 1.5g in 100 mL 0.9% NS over 45 minutes: Round to the whole number.

Choice A reason:
Increasing serum potassium levels would not indicate effective therapy for a patient with Addison's disease. In Addison's disease, the adrenal glands do not produce enough aldosterone, which is responsible for regulating sodium and potassium balance. As a result, patients with Addison’s disease often experience hyperkalemia (high potassium levels). Effective therapy typically aims to normalize potassium levels, so an increase would suggest inadequate treatment or worsening of the condition.
Choice B reason:
Decreasing blood glucose levels would not typically be seen as a positive indicator in a patient with Addison's disease. The body’s ability to maintain normal blood glucose levels is compromised in Addison’s disease due to a deficiency in cortisol. Cortisol plays a key role in regulating glucose metabolism, and its deficiency can lead to hypoglycemia (low blood glucose levels). If blood glucose levels are decreasing, it may indicate inadequate glucocorticoid replacement therapy, suggesting the therapy is not fully effective.
Choice C reason:
Decreasing serum chloride levels would not be expected in a patient with Addison’s disease who is receiving proper treatment. Chloride is regulated alongside sodium and is influenced by aldosterone. In Addison's disease, aldosterone deficiency leads to a decreased ability to retain sodium, which in turn can affect chloride levels. However, a decrease in chloride levels alone is not a clear sign of effective therapy. Normalization of serum sodium levels is a better indicator of treatment success.
Choice D reason:
Increasing serum sodium levels is the correct finding that indicates effective therapy in a patient with Addison’s disease. In this condition, aldosterone deficiency results in sodium loss through the kidneys, leading to hyponatremia (low sodium levels). Effective therapy, which typically involves the administration of glucocorticoids and mineralocorticoids (such as fludrocortisone), helps to correct this imbalance by increasing sodium retention and normalizing serum sodium levels. This would demonstrate that the current therapies are working to restore the electrolyte balance.

Choice A reason: Addison's Disease is characterized by insufficient production of adrenal hormones, leading to symptoms like weight loss, hyperpigmentation, low blood pressure, and severe fatigue. The lab findings would typically show low sodium, high potassium, and low cortisol levels. RM's lab results and symptoms are not consistent with Addison's Disease, making this an unlikely diagnosis.
Choice B reason: Cushing syndrome results from excess cortisol production, often causing weight gain, particularly around the abdomen and face, thinning skin, and hypertension. RM's symptoms of fatigue, dry skin, hair loss, and weight gain without dietary changes do not align with Cushing syndrome, and her lab results do not indicate elevated cortisol levels.
Choice C reason: Hyperthyroidism is characterized by excessive thyroid hormone production, leading to symptoms like weight loss, anxiety, palpitations, and heat intolerance. RM's symptoms of weight gain, fatigue, and cold intolerance, along with her lab results showing low T4 and T3 and elevated TSH, are not consistent with hyperthyroidism.
Choice D reason: Hypothyroidism occurs due to an underactive thyroid gland producing insufficient thyroid hormones. This leads to symptoms such as fatigue, weight gain, cold intolerance, dry skin, hair loss, and constipation. RM's lab results showing low T4 and T3 levels and elevated TSH align with the diagnosis of hypothyroidism. The body's response to low thyroid hormone levels is to increase TSH production in an attempt to stimulate the thyroid gland. The clinical presentation and lab findings point towards hypothyroidism as the correct diagnosis.