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Modifiable risk factors for coronary artery disease (CAD) are those that can be changed or controlled to reduce the risk of developing CAD. These include high blood pressure, high cholesterol levels, smoking, physical inactivity, unhealthy diet, and obesity. High HDL (high-density lipoprotein) is actually a desirable factor, as it is known as the "good cholesterol" and helps to remove excess cholesterol from the body. Orthostatic hypotension, or a drop in blood pressure upon standing, is not considered a modifiable risk factor for CAD.

Coronary artery disease (CAD) is a condition where the arteries that supply blood to the heart become narrowed or blocked due to a buildup of plaque. Several risk factors contribute to the development of CAD, including diabetes mellitus, hypertension, obesity, high alcohol consumption, smoking, and a family history of CAD.

Research suggests that individuals with diabetes mellitus are two to four times more likely to develop CAD than those without diabetes. This is because diabetes can lead to damage to the blood vessels and nerves that control the heart, as well as increased inflammation and high levels of blood glucose that can contribute to the buildup of plaque in the arteries.

While hypertension, obesity, and high alcohol consumption are also known risk factors for CAD, they generally do not increase the risk to the same degree as diabetes. Nonetheless, these factors can contribute to the development and progression of CAD and should be addressed through lifestyle modifications and medical interventions.