Continuous increases in left ventricular filling pressures result in which disorder

The walls of the atria are thin because they do not generate as much pressure as the ventricles, as their main function is to receive blood from the veins and pump it into the ventricles. The ventricles have thicker walls because they are responsible for generating the force necessary to pump blood out of the heart and into the systemic or pulmonary circulation.

Atherosclerosis is a complex disease process that involves the gradual buildup of plaques (fatty deposits) in the walls of arteries, leading to narrowing and reduced blood flow. The exact cause of atherosclerosis is not fully understood, but it is thought to involve a combination of genetic, lifestyle, and environmental factors

One of the key contributing factors to atherosclerosis is damage to the endothelial cells that line the walls of arteries. This damage can be caused by a variety of factors, including high blood pressure, smoking, high levels of lowdensity lipoprotein (LDL) cholesterol, and other inflammatory factors. When the endothelial cells are damaged, they release chemicals that attract white blood cells to the area. These white blood cells then migrate into the arterial wall, where they begin to accumulate and form fatty deposits called plaques.

Over time, these plaques can grow and calcify, leading to further narrowing of the artery and reducing blood flow to the affected tissue. In addition, plaques can rupture and form blood clots, which can completely block blood flow to the affected area and cause a heart attack or stroke.

While high serum cholesterol levels are a risk factor for atherosclerosis, they are not the sole cause. Similarly, an increase in antithrombotic substances (substances that prevent blood clots) and congenital heart disease are not primary causes of atherosclerosis, although they may contribute to the disease process in some cases.