How does Paget's disease differ from osteoporosis?
Paget's disease is characterized by decreased bone density, while osteoporosis is associated with increased bone density.
Paget's disease primarily affects trabecular bone, while osteoporosis affects cortical bone.
Paget's disease involves abnormal bone remodeling and increased bone turnover, while osteoporosis involves decreased bone formation and increased bone resorption.
Paget's disease is an autoimmune disorder, while osteoporosis is caused by hormonal imbalances.
The Correct Answer is C
The main difference between Paget's disease and osteoporosis is in the underlying bone remodeling. Paget's disease is characterized by increased bone turnover and disordered bone formation, while osteoporosis involves decreased bone formation and increased bone resorption.
a. Paget's disease is characterized by decreased bone density, while osteoporosis is associated with increased bone density: This statement is incorrect. In Paget's disease, bone density can be normal or increased due to the disordered bone remodeling.
b. Paget's disease primarily affects trabecular bone, while osteoporosis affects cortical bone: This statement is incorrect. Both Paget's disease and osteoporosis can affect both trabecular and cortical bone.
d. Paget's disease is an autoimmune disorder, while osteoporosis is caused by hormonal imbalances: This statement is incorrect. Paget's disease is not an autoimmune disorder, and osteoporosis is not solely caused by hormonal imbalances. Both conditions have complex multifactorial etiologies.
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Correct Answer is D
Explanation
Bone pain is a common clinical manifestation of Paget's disease, but another hallmark of the condition is the development of bone deformities. The abnormal bone remodeling in Paget's disease can lead to enlarged, misshapen bones, particularly in weight-bearing areas such as the skull, pelvis, and long bones.
a. Muscle weakness: While bone pain can lead to discomfort and reduced mobility, muscle weakness is not a specific clinical manifestation of Paget's disease.
b. Hypercalcemia: Hypercalcemia (elevated blood calcium levels) is not typically associated with Paget's disease. Instead, the condition is characterized by disorganized bone remodeling.
c. Joint swelling: Joint swelling is not a primary clinical manifestation of Paget's disease. Bone deformities are more characteristic of the condition.
Correct Answer is B
Explanation
A bone scan is the most appropriate diagnostic test for confirming the diagnosis of Paget's disease. It can reveal increased bone turnover and abnormal bone remodeling patterns characteristic of the condition. The bone scan can show "hot spots" of increased uptake in affected bones.
a. Complete blood count (CBC): While a CBC can be useful in ruling out other conditions, it does not directly diagnose Paget's disease. Specific bone imaging is required for confirmation.
c. Liver function tests (LFTs): Liver function tests are not used to diagnose Paget's disease. The condition primarily affects bone structures, and liver involvement is not a primary concern.
d. Magnetic resonance imaging (MRI): While an MRI can provide detailed images of bones and soft tissues, it may not be the initial choice for diagnosing Paget's disease. A bone scan is more specific to evaluate bone turnover and remodeling.
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