Which cell type is primarily responsible for the increased bone resorption seen in Paget's disease?
Osteocytes
Osteoblasts
Osteoclasts
Osteoprogenitor cells
The Correct Answer is C
Osteoclasts are the primary cell type responsible for bone resorption in Paget's disease. These cells become overactive, leading to excessive bone breakdown, which is a hallmark of the condition.
a. Osteocytes: Osteocytes are mature bone cells embedded in the bone matrix. While they play a role in maintaining bone health, they are not directly responsible for bone resorption.
b. Osteoblasts: Osteoblasts are bone-forming cells. In Paget's disease, they attempt to repair the resorbed bone but their activity is disordered, leading to structurally abnormal bone formation.
d. Osteoprogenitor cells: Osteoprogenitor cells are undifferentiated cells that can differentiate into osteoblasts. They are not directly involved in the increased bone resorption seen in Paget's disease.
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Related Questions
Correct Answer is C
Explanation
X-ray imaging is commonly used to confirm the diagnosis of Paget's disease. X-rays can show characteristic bone changes, such as bone enlargement, thickening, and deformities, which are indicative of Paget's disease.
a. Bone density scan: While bone density scans may be useful to assess bone health in other conditions, they are not the primary diagnostic tool for Paget's disease. X-rays are preferred.
b. Magnetic resonance imaging (MRI): MRI may provide detailed images of bones and surrounding soft tissues, but it is not the first-line diagnostic test for Paget's disease. X-rays are more commonly used.
d. Blood glucose test: A blood glucose test is used to diagnose and monitor diabetes, not Paget's disease. These conditions are unrelated.
Correct Answer is D
Explanation
The most common clinical manifestation of Paget's disease is bone pain and deformities due to abnormal bone remodeling and increased bone turnover.
a. Severe joint pain: While joint pain can occur in Paget's disease due to bone involvement, it is not the most common manifestation. Bone pain and deformities are more characteristic.
b. Unexplained weight loss: Unexplained weight loss is not a typical symptom of Paget's disease. It is not directly related to the bone disorder.
c. Visual disturbances: Visual disturbances are not associated with Paget's disease. This condition primarily affects bones, not the eyes or vision.
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