Which cell type is primarily responsible for the increased bone resorption seen in Paget's disease?
Osteocytes
Osteoblasts
Osteoclasts
Osteoprogenitor cells
The Correct Answer is C
Osteoclasts are the primary cell type responsible for bone resorption in Paget's disease. These cells become overactive, leading to excessive bone breakdown, which is a hallmark of the condition.
a. Osteocytes: Osteocytes are mature bone cells embedded in the bone matrix. While they play a role in maintaining bone health, they are not directly responsible for bone resorption.
b. Osteoblasts: Osteoblasts are bone-forming cells. In Paget's disease, they attempt to repair the resorbed bone but their activity is disordered, leading to structurally abnormal bone formation.
d. Osteoprogenitor cells: Osteoprogenitor cells are undifferentiated cells that can differentiate into osteoblasts. They are not directly involved in the increased bone resorption seen in Paget's disease.
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Related Questions
Correct Answer is B
Explanation
The goal of treatment for Paget's disease is to relieve pain and prevent complications associated with bone deformities and fractures. There is no cure for Paget's disease, but treatment aims to manage symptoms and reduce the risk of complications.
a. Cure the disease completely: Paget's disease is a chronic condition with no known cure. Treatment focuses on symptom management and preventing complications.
c. Restore normal bone density: While treatment may aim to reduce abnormal bone remodeling, restoring normal bone density is not typically achievable. The focus is on pain relief and preventing complications.
d. Regenerate damaged bones: While treatment may improve bone health and reduce deformities, regenerating damaged bones to their original state is not feasible. Treatment aims to manage the disease and its consequences effectively.
Correct Answer is C
Explanation
The characteristic X-ray finding in Paget's disease is bony overgrowth and thickening of the affected bones. This is due to the increased bone turnover and abnormal remodeling associated with the condition.
a. Decreased bone density: Decreased bone density is associated with osteoporosis, not Paget's disease. In Paget's disease, bone density is often normal or increased due to the disorganized bone remodeling.
b. Erosions and bone cysts: Erosions and bone cysts are not specific to Paget's disease and may be seen in other bone conditions. Bony overgrowth is more characteristic of Paget's disease.
d. Presence of osteoporotic fractures: Osteoporotic fractures are not typically associated with Paget's disease. The increased bone density and thickening in Paget's disease can actually make bones more resistant to fractures.
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