Which cell type is primarily responsible for the increased bone resorption seen in Paget's disease?
Osteocytes
Osteoblasts
Osteoclasts
Osteoprogenitor cells
The Correct Answer is C
Osteoclasts are the primary cell type responsible for bone resorption in Paget's disease. These cells become overactive, leading to excessive bone breakdown, which is a hallmark of the condition.
a. Osteocytes: Osteocytes are mature bone cells embedded in the bone matrix. While they play a role in maintaining bone health, they are not directly responsible for bone resorption.
b. Osteoblasts: Osteoblasts are bone-forming cells. In Paget's disease, they attempt to repair the resorbed bone but their activity is disordered, leading to structurally abnormal bone formation.
d. Osteoprogenitor cells: Osteoprogenitor cells are undifferentiated cells that can differentiate into osteoblasts. They are not directly involved in the increased bone resorption seen in Paget's disease.
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Related Questions
Correct Answer is B
Explanation
Assisting with range-of-motion exercises is important when caring for a patient with Paget's disease. Range-of-motion exercises can help maintain joint mobility and prevent joint contractures, which may occur due to bone changes in the disease.
a. Encouraging bed rest to prevent fractures: Bed rest is not recommended for individuals with Paget's disease, as it can lead to muscle weakness and joint stiffness.
c. Administering corticosteroids to reduce inflammation: Corticosteroids are not typically used to treat Paget's disease, as they do not address the underlying bone changes.
d. Providing a high-calcium diet: While adequate calcium intake is important for bone health, a high-calcium diet is not a specific nursing intervention for Paget's disease. Bisphosphonates are typically prescribed to address bone changes.
Correct Answer is C
Explanation
Individuals with Paget's disease should be encouraged to engage in walking and low-impact exercises to promote bone health. These activities are less likely to cause fractures or stress on the bones while still supporting bone strength and density.
a. Participating in high-impact sports: High-impact sports can put excessive stress on the bones and increase the risk of fractures in individuals with Paget's disease. It is not recommended.
b. Limiting physical activity to avoid fractures: While excessive physical activity may need to be moderated to prevent fractures, limiting all physical activity is not advisable. Moderate exercise is essential for overall health and bone strength.
d. Heavy weightlifting: Heavy weightlifting can increase the risk of fractures in individuals with Paget's disease. It is not recommended, as it can put excessive stress on the bones.
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